Maxillary Ameloblastoma, Conventional, Mixed Pattern of Acanthomatous and Basal Cell Subtypes; A Rare Case Report

Noriko Matsuzawa¹, Hideki Mori², Yoshihiro Kimura³ and Mitsuhiro Aoki^4,

¹Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465, Kaji-cho, Hirokoji-Kawaramachi, Kyoto City, Kyoto, Japan

²Department of Diagnostic Pathology, Ogaki Tokushukai Hospital, 6-85 Hayashi-Machi, Ogaki City, Gifu, Japan

³Department of Dental and Oral Surgery, Ogaki Tokushukai Hospital, 6-85 Hayashi-Machi, Ogaki City, Gifu, Japan

⁴Department of Otolaryngology, Ogaki Toshukai Hospital, 6-85 Hayashi-Machi, Ogaki City Japan

Cite this paper:
Noriko Matsuzawa, Hideki Mori, Yoshihiro Kimura and Mitsuhiro Aoki. Maxillary Ameloblastoma, Conventional, Mixed Pattern of Acanthomatous and Basal Cell Subtypes; A Rare Case Report. American Journal of Medical Case Reports. 2026; 14(9):79-82. doi: 10.12691/ajmcr-14-9-1

Abstract

Ameloblastoma (AM) is a benign but locally infiltrative epithelial odontogenic neoplasm. An 86-year-old woman presented with swelling on the left palate gum. CT images as well as panoramic X-ray photograph displayed a multiocular radiolucent lesion extending from the alveolar process to the plate. Pathological diagnosis of the resected tumor tissue was AM arisen from the anterior maxillary bone. AM can present with a follicular, plexiform, acanthomatous, basal cell, granular or desmoplastic subtype. Present case was diagnosed as a mixed pattern of acanthomatous subtype and basal cell subtype. In this study, tumor cells of the basal cell type had a clear continuity to the islands of acanthomatous subtype suggesting that the cells of basal type could differentiate to those of acanthomatous islands. To the best of our knowledge, presence of the unique combination of acanthomatous subtype and basal cell subtype, and the mutual correlation with two subtypes of AM have not yet been described.

Keywords:
Ameloblastoma Maxillary Acanthomatous Basal Cell Mixed pattern

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References:

[1]	Evangelou Z, Zarachi A, Dumollard JM, Peoc'h M, Komnos I, Kastanioudakis I, Karpathiou G, “Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor”, In Vivo, 34(5), 2249-2258, Sep, 2020.
[2]	Broca P, Recherches sur un nouveau groupe de tumeurs désignées sous le nom d’odontomes (ed.1867), HACHETTE BNF, 2017.
[3]	Small IA, Waldron CA, “Ameloblastomas of the jaws”, Oral Surg Oral Med Oral Pathol, 8(3), 281-297, Mar, 1955.
[4]	Robinson HBG, “Histologic study of the ameloblastoma”. Arch Pathol, 23, 664–673, 1937.
[5]	Reichart PA、Philipsen HP, Sonner S, “Ameloblastoma: biological profile of 3677 cases”, Eur J Cancer Part B Oral Oncol, 31B(2), 86-99, Mar, 1995.
[6]	Sehdev MK, Huvos AG, Strong EW, Gerold FP, Willis GW, “Proceedings: Ameloblastoma of maxilla and mandible”, Cancer, 33(2), 324-333, Feb, 1974.
[7]	Vered M, Wright JM, “Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours”, Head Neck Pathol, 16(1), 63-75, Mar, 2022.
[8]	Hendra FN, Cann EV, Helder MN, Ruslin M, Visscher J, Forouzanfar T, Vet H-C-W, “Global incidence and profile of ameloblastoma: A systematic review and meta-analysis”, Oral Dis, 26(1), 12-21, Jan, 2020.
[9]	Zlotogorski-Hurvitz A, Tekkesin MS, Passador-Santos F, Montalli VCM, Salo T, Mauramo M, Kats L, Buchner A, Vered M, “Conceptual changes in ameloblastoma: Suggested re-classification of a "veteran" tumor”, Oral Dis, 28(3), 703-710, Apr, 2022.
[10]	Filizzola A-I, Bartholomeu-dos-Santos T-C-R, Pires F-R, “Ameloblastomas: clinicopathological features from 70 cases diagnosed in a single oral pathology service in an 8-year period”, Med Oral Patol Oral Cir Bucal, 19(6), e556-e561, Nov, 2014.
[11]	Tomar A, “Plexiform Ameloblastoma with Acanthomatous Changes: A Rare Case Report”, Ind J Otolaryng Head Neck Surg, 76(6), 6028-3601, Sep, 2024.
[12]	Ghattamaneni S, Guttikonda VR, Kumari MG, Kumar DR, “Maxillary plexiform ameloblastoma showing basaloid differentiation: Report of a rare case with review of literature”, Ind J Dental Res, 26(6), 633-636, Nov, 2015.
[13]	Gonzalez-Alva P, Tanaka A, Oku Y, Miyazaki Y, Okamoto E, Fujinami M, Yoshida N, Kikuchi K, Ide F, Sakashita H, Kusama K, “Enhanced expression of podoplanin in ameloblastomas” J Oral Pathol Med, 39(1), 103-109, Jan, 2010.
[14]	Martinez M, Taylor A, Bregni R, Pires F-R, Azanero W, Silva R, Barrios B, Almeida O, “Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas”, Med Oral Patol Oral Cir Bucal, 22(3), 324-332, Apr, 2017.
[15]	15.Vickers RA, Gorlin RJ, “Ameloblastoma: Delineation of early histopathologic features of neoplasia”, Cancer, 26(3), 699-710, Sep, 1970.
[16]	16.Pincock HP, Bruce KW, “Odontogenic fibroma”, Oral Surg Oral Med Oral Path, 7(3), 307-311, 1954.