Clinical Presentation and Successful Treatment of a Patient with Anti-SUMO-activating Enzyme Subunit 1 (SAE1) Dermatomyositis

Adrian M. Alonso^1, and Matilda L. Culp¹

¹University of Florida, Department of Internal Medicine1, Gainesville, FL

Cite this paper:
Adrian M. Alonso and Matilda L. Culp. Clinical Presentation and Successful Treatment of a Patient with Anti-SUMO-activating Enzyme Subunit 1 (SAE1) Dermatomyositis. American Journal of Medical Case Reports. 2023; 11(11):167-168. doi: 10.12691/ajmcr-11-11-1

Abstract

Anti-SAE1 antibody is a rarely reported, myositis-specific antibody, which is most clinically associated with affecting the gastrointestinal tract, skin, and lungs. This case demonstrates a patient presenting to the hospital with signs of dermatomyositis, later found to be anti-SAE1 positive. He was promptly treated with immunosuppressive medications, including IVIG, a novel therapeutic agent for dermatomyositis. This case further elucidates the importance of identifying anti-SAE1-positive patients in dermatomyositis.

Keywords:
dermatomyositis anti-SAE1 polymyositis antibody immunology

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References:

[1]	Aggarwal R., Clodi E, Beckmann I., et al. (2023) Trial of intravenous immune globulin in dermatomyositis. New England Journal of Medicine.
[2]	Betteridge Z., Tansley S., Shaddick G., Chinoy H., Cooper RG., New RP., Lilleker JB., Vencovsky J., Chazarain L., Danko K., Nagy-Vincze M., Bodoki L., Dastmalchi M., Ekholm L., Lundberg IE., McHugh N; (2019) UKMyonet contributors. Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients. J Autoimmun. 2019.
[3]	de Vries M., Schreurs MWJ., Ahsmann EJM., Spee-Dropkova M., Karim F. (2022) A Case of Anti-SAE1 Dermatomyositis. Case Reports Immunol.
[4]	Juliette Demortier., Mathieu Vautier., Olivier Chosidow., Laure Gallay., Didier Bessis., Alice Berezne., Nadège Cordel., Jean Schmidt., Amar Smail., Pierre Duffau., Marie Jachiet., Edouard Begon., Jeremy Gottlieb., François Chasset., Julie Graveleau., Myriam Marque., Elise Cesbron., Amandine Forestier., Séverine Josse., Nicolas Kluger., Caroline Beauchêne., Yannick Le Corre., Valentine Pagis., Aude Rigolet., Perrine Guillaume-Jugnot., François-Jérôme Authier., Nelly Guilain., Nathalie Streichenberger., Sarah Leonard-Louis., Samia Boussouar., Océane Landon-Cardinal., Olivier Benveniste., Yves Allenbach. (2023) Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature, Rheumatology.
[5]	Zamora, A. C., Hoskote, S. S., Abascal-Bolado, B., White, D., Cox, C. W., Ryu, J. H., & Moua , T. (2016). Clinical features and outcomes of interstitial lung disease in anti-Jo-1 positive antisynthetase syndrome. Respiratory Medicine.