A Case of Paraneoplastic Arthralgias

David Pisarcik^1, , Gabriel Kousourou² and Nagadarshini Vinod²

¹Department of Medicine, Indiana University, Indianapolis, IN, USA

²Department of Rheumatology, Indiana University, Indianapolis, IN, USA

Cite this paper:
David Pisarcik, Gabriel Kousourou and Nagadarshini Vinod. A Case of Paraneoplastic Arthralgias. American Journal of Medical Case Reports. 2021; 9(8):397-401. doi: 10.12691/ajmcr-9-8-4

Abstract

Hypertrophic Osteoarthropathy (HOA) is a rare condition that presents with arthralgias, digital clubbing, and abnormal periosteal bone deposition seen on x rays. The secondary form of HOA may be associated with an underlying malignancy, thus highlighting the importance of early clinical recognition. We present the case of a 44-year-old woman who presented with several weeks of lower extremity swelling, arthralgias, and digital clubbing who was later found to have non-small cell lung cancer. Diagnosis can be challenging due to variable presentations that can often mimic other forms of inflammatory arthritis. Treatment is focused on addressing the underlying cause. Nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used for pain relief while intravenous bisphosphonates have been trialed with some success in case reports.

Keywords:
paraneoplastic syndrome arthralgias clubbing periostosis hypertrophic osteoarthropathy

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