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Harada, Shun-ichi, et al. “Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.” The Journal of clinical investigation. 93.6 (1994): 2490-2496.

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Article

A Case of Paraneoplastic Arthralgias

1Department of Medicine, Indiana University, Indianapolis, IN, USA

2Department of Rheumatology, Indiana University, Indianapolis, IN, USA


American Journal of Medical Case Reports. 2021, Vol. 9 No. 8, 397-401
DOI: 10.12691/ajmcr-9-8-4
Copyright © 2021 Science and Education Publishing

Cite this paper:
David Pisarcik, Gabriel Kousourou, Nagadarshini Vinod. A Case of Paraneoplastic Arthralgias. American Journal of Medical Case Reports. 2021; 9(8):397-401. doi: 10.12691/ajmcr-9-8-4.

Correspondence to: David  Pisarcik, Department of Medicine, Indiana University, Indianapolis, IN, USA. Email: dapisa@iu.edu

Abstract

Hypertrophic Osteoarthropathy (HOA) is a rare condition that presents with arthralgias, digital clubbing, and abnormal periosteal bone deposition seen on x rays. The secondary form of HOA may be associated with an underlying malignancy, thus highlighting the importance of early clinical recognition. We present the case of a 44-year-old woman who presented with several weeks of lower extremity swelling, arthralgias, and digital clubbing who was later found to have non-small cell lung cancer. Diagnosis can be challenging due to variable presentations that can often mimic other forms of inflammatory arthritis. Treatment is focused on addressing the underlying cause. Nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used for pain relief while intravenous bisphosphonates have been trialed with some success in case reports.

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