NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose

Andrew V. Doodnauth¹, Fadi Yacoub¹, Vaibhavi Solanki¹, Andrea Trimmingham¹, Lina Soni¹ and Samy I. McFarlane^1,

¹Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203

Cite this paper:
Andrew V. Doodnauth, Fadi Yacoub, Vaibhavi Solanki, Andrea Trimmingham, Lina Soni and Samy I. McFarlane. NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose. American Journal of Medical Case Reports. 2021; 9(3):194-197. doi: 10.12691/ajmcr-9-3-15

Abstract

Thyroid hormone has a major role in cardiovascular function and cardiac hemodynamics. A slight change in thyroid affects ventricular function, serum cholesterol levels, increases the risk of coronary artery disease as well as cardiovascular mortality. In this report, we present a 62-year-old female with history significant for ischemic heart disease who was admitted for acute coronary syndrome (ACS) with persistent tachycardia, requiring urgent cardiac catheterization. Complete cardiac workup revealed that the patient had most likely suffered from vasospastic angina secondary to inadvertent overdose of her prescribed levothyroxine. This report emphasizes the significant cardiac complications caused by a deluged hyperadrenergic state secondary to overt hyperthyroidism. We conclude that thyrotoxicosis is a significant risk factor for cardiovascular disease and should be considered as a cause of life-threatening myocardial ischemia, especially in patients with known ischemic heart disease and thyroid disorders.

Keywords:
thyroid hormone ischemic heart disease acute coronary syndrome levothyroxine hyperthyroidism cardiovascular disease

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