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De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet. 2016 Aug 27; 388(10047): 906-918.

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Article

NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose

1Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203


American Journal of Medical Case Reports. 2021, Vol. 9 No. 3, 194-197
DOI: 10.12691/ajmcr-9-3-15
Copyright © 2021 Science and Education Publishing

Cite this paper:
Andrew V. Doodnauth, Fadi Yacoub, Vaibhavi Solanki, Andrea Trimmingham, Lina Soni, Samy I. McFarlane. NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose. American Journal of Medical Case Reports. 2021; 9(3):194-197. doi: 10.12691/ajmcr-9-3-15.

Correspondence to: Samy  I. McFarlane, Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203. Email: Smcfarlane@downstte.edu

Abstract

Thyroid hormone has a major role in cardiovascular function and cardiac hemodynamics. A slight change in thyroid affects ventricular function, serum cholesterol levels, increases the risk of coronary artery disease as well as cardiovascular mortality. In this report, we present a 62-year-old female with history significant for ischemic heart disease who was admitted for acute coronary syndrome (ACS) with persistent tachycardia, requiring urgent cardiac catheterization. Complete cardiac workup revealed that the patient had most likely suffered from vasospastic angina secondary to inadvertent overdose of her prescribed levothyroxine. This report emphasizes the significant cardiac complications caused by a deluged hyperadrenergic state secondary to overt hyperthyroidism. We conclude that thyrotoxicosis is a significant risk factor for cardiovascular disease and should be considered as a cause of life-threatening myocardial ischemia, especially in patients with known ischemic heart disease and thyroid disorders.

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