The Leading Pathogenic Mechanism of Endothelial Dysfunction in Patient with Acute Coronary Syndrome

Kenjaev Magid Latipovich¹, Abdijalilova Salima Inomidinova¹, Ganiev Ulugbek Shuhratovich¹, Kholov Gulom Anvarovich¹ and Shakirov Babur Magrufovich^2,

¹Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan

²Burn department of RSCUMA, Samarkand, Uzbekistan

Cite this paper:
Kenjaev Magid Latipovich, Abdijalilova Salima Inomidinova, Ganiev Ulugbek Shuhratovich, Kholov Gulom Anvarovich and Shakirov Babur Magrufovich. The Leading Pathogenic Mechanism of Endothelial Dysfunction in Patient with Acute Coronary Syndrome. American Journal of Hypertension Research. 2014; 2(1):8-10. doi: 10.12691/ajhr-2-1-2

Abstract

The problem of ischemic heart disease (IHD) remains important among cardiovascular diseases. The problem of diagnostics and treatment of acute coronary syndrome (ACS) and its complications are also considered to be vital questions. Between 2009 and 2012, 80 patients (69 males and 11 females) who had acute coronary syndrome with elevation of ST segment admitted to the Cardioresuscitation Department of RSCEMA were enrolled in the study. All patients were divided into 2 groups: the 1^st - group included 80 ACS patients with ST segment elevation, and the 2d - group included 40 ACS patients without ST segment elevation. During the study we observed that increase of stable nitric oxide (NO3, NO2+NO3) metabolites is noted in patients with acute coronary syndrome without ST segment elevation, unlike ACS patients with ST segment elevation. On the basis of these findings it is possible to make a conclusion that in the development of unfavorable coronary events in ACS patients without ST segment elevation vasoconstructive mechanism (endothelia-1) takes place and in ACS patients without ST segment elevation the findings of changes are not so clearly marked. Thus, at present the study of markers of endothelial dysfunction and no specific inflammation is of great interest for estimation prognosis and follow-up outcomes in ACS patients.

Keywords:
acute coronary syndrome nitric oxide endothelial dysfunction endothelin-1

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics--2010 update: a report from the American Heart Association. 2010; 121(7): e46–e215.
[2]	Carney RM, Freedland KE. Depression in patients with coronary heart disease. Am J Med. 2008; 121(11 Suppl. 2):S20–27.
[3]	Bush DE, Ziegelstein RC, Patel UV, et al. Post - myocardial Infarction Depression. Washington, DC: Agency for Healthcare Research and Quality; 2005. p.123.
[4]	Van Melle JP, de Jonge P, Spijkerman TA, et al. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med. 2004; 66(6): 814-822.
[5]	Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. European Heart Journal. 2006; 27(23): 2763-2774.
[6]	Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003; 290(2): 215-221.
[7]	Akira, S. Interleukin- biology and medicine / S. Akira, T. Taga, T. Kishimoto //Adv. Immunol. - 1993. - Vol. 54. - P. 1-78.
[8]	Gray M. O. et al. // Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-Pi and endothelin-1 from fibroblasts / Cardiovasc Res. - 1998. - Vol. 40. - P. 352-363.
[9]	Ciccone MM et al. Cardiovasc Ultrasound. 2011 Nov. 16; 9: 32.
[10]	Ciccone MM et al. Int Heart J. 2011; 52(2):72-7.
[11]	Abdelmeguid A.E. The myth of the myocardial 'infarctlet' during percutaneous coronary revascularization procedures / A. E. Abdelmeguid, E. J. Topol // Circulation. - 1996. - Vol. 94. - P. 3369-3375.
[12]	Smith S.C., Dove J. T. et al. ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines) - executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) / //J. Am. Coll. Cardiol. -2001. - Vol. 37. - P. 2215-2239.
[13]	Holmes D. R. et al. Application of the New York State PTCA mortality model in patients undergoing stent implantation / // Circulation. - 2000. - Vol. 102. - P. 517-522.
[14]	Ciccone M.M. et al. J Cardiovasc Med (Hagerstown). 2013 Oct; 14(10):757-66.
[15]	Mintz S.A., Popma J. J. et al. Arterial remodeling after coronary angioplasty: A serial intravascular ultrasound study / G. // Circulation. - 1996. - Vol. 94. - P. 35-43.