Kenjaev Magid Latipovich¹, Abdijalilova Salima Inomidinova¹, Ganiev Ulugbek Shuhratovich¹, Kholov Gulom Anvarovich¹, Shakirov Babur Magrufovich^2,

The problem of ischemic heart disease (IHD) remains important among cardiovascular diseases. The problem of diagnostics and treatment of acute coronary syndrome (ACS) and its complications are also considered to be vital questions. Between 2009 and 2012, 80 patients (69 males and 11 females) who had acute coronary syndrome with elevation of ST segment admitted to the Cardioresuscitation Department of RSCEMA were enrolled in the study. All patients were divided into 2 groups: the 1^st - group included 80 ACS patients with ST segment elevation, and the 2d - group included 40 ACS patients without ST segment elevation. During the study we observed that increase of stable nitric oxide (NO3, NO2+NO3) metabolites is noted in patients with acute coronary syndrome without ST segment elevation, unlike ACS patients with ST segment elevation. On the basis of these findings it is possible to make a conclusion that in the development of unfavorable coronary events in ACS patients without ST segment elevation vasoconstructive mechanism (endothelia-1) takes place and in ACS patients without ST segment elevation the findings of changes are not so clearly marked. Thus, at present the study of markers of endothelial dysfunction and no specific inflammation is of great interest for estimation prognosis and follow-up outcomes in ACS patients.

acute coronary syndrome, nitric oxide, endothelial dysfunction, endothelin-1