Laser Ablation Synthesized Copper Nanoparticles for Cancer Treatment: An Animal Cell Line Studies

Mahadevaiah¹, Nawneet K. Kurrey², Gowtham G. K³, Thejas Urs G¹ and Somashekar R^1,

¹Center for Materials Science, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore – 570006

²Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysuru – 570020

³Department of Physics, Yuvarajas College, University of Mysore, Mysore – 570005

Cite this paper:
Mahadevaiah, Nawneet K. Kurrey, Gowtham G. K, Thejas Urs G and Somashekar R. Laser Ablation Synthesized Copper Nanoparticles for Cancer Treatment: An Animal Cell Line Studies. American Journal of Cancer Prevention. 2018; 6(2):35-40. doi: 10.12691/ajcp-6-2-5

Abstract

Drive of nanoparticles in all arenas of science, have essentially attracted the field of medicine and medical sciences. Role of nano particles in drug delivery and targeting is been on its peak in alluring researchers. In this concern, to evaluate and check the adaptability we have made an attempt in using pure metal nanoparticles for cancer inhibition. Pure Copper nanoparticles (CuNPs) were synthesized employing laser ablation in distilled water media. Formations of CuNPs were confirmed by EDAX and this is supported by UV-Visible spectra. The particle size these metal clusters were analyzed by DLS. To understand the biological inhibiting potential of these NPs we have studied on normal and cancers cells. MTT assay result indicates no evidence of in vitro cytotoxity in the normal cells treated with CuNPs. Cell morphology, cell proliferation and viability were examined for exposed cell lines and the effects were quantified in terms cells cytotoxicity using standard procedures. Study reveals the effect of nanoparticles on cancerous cells of Breast, Melanoma and Colon origin and normal fibroblast cells. Furthermore, result demonstrated the distinct role of nanoparticles in normal and cancer cells of different origin with an inference that specific nanoparticles were effective in controlling particular cancer. This study provides fundamental evidence for the easy, simple and safe mode of nanoparticles synthesis and their application in inhibiting/killing cancer cells.

Keywords:
copper nanoparticles laser ablation cancer treatment cell line studies nanoparticles

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