Expression of p53 and Ki67 in the Patients with Triple Negative Breast Cancer and Invasive Ductal Carcinoma

Mehrdad Payandeh¹, Reza Malayeri², Masoud Sadeghi^{3, 4,} , Edris Sadeghi^{3, 4} and Faezeh Gholami³

¹Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

²Breast Cancer Research Center, Tehran, Iran

³Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

⁴Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Cite this paper:
Mehrdad Payandeh, Reza Malayeri, Masoud Sadeghi, Edris Sadeghi and Faezeh Gholami. Expression of p53 and Ki67 in the Patients with Triple Negative Breast Cancer and Invasive Ductal Carcinoma. American Journal of Cancer Prevention. 2015; 3(3):58-61. doi: 10.12691/ajcp-3-3-3

Abstract

Background: Breast cancer is the most common cancer (27% of all cancers) and common cause of death (16%) which occurs due to cancers among women, either in developed or developing. The aim of study is to evaluated clinicopathology figures especially Tumor markers such as Ki6 and p53 in the patients with TNBC. Materials and Methods: Between of 2005 to 2014, 50 patients with triple negative breast cancer and invasive ductal carcinoma referred to our Clinic. Age, sex, metastasis, Ki67, p53, laterality, treatment options and The OS were checked in the patients. Results: The mean age for the patients at diagnosis was 51.04, 100% female. We divided the patients based on Ki67 to two groups, 24 patients (48%) with low Ki67 (<10%) and 26 patients (52%) with high Ki67 (≥10%). Also, Seventeen patients (34%) had P53 positive. There were statistically significant correlation between of Ki-67 with p53 and laterality (P<0.05). The OS for all of patients that the mean survival for them was 39.4 months and survival rate was 67.5%. Conclusions: The OS in our patients was lower than other studies. Also, there is a direct correlation between Ki67 and p53 in TNBC patients that for better conclusion it needs more studies.

Keywords:
Ki67 overall survival P53 TNBC

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