Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells

Lujiang Yi¹, Ye Jiang¹ and Lu Yang^2,

¹#These authors contributed equally to this work.

²Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China

Cite this paper:
Lujiang Yi, Ye Jiang and Lu Yang. Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells. American Journal of Clinical Medicine Research. 2021; 9(1):10-13. doi: 10.12691/ajcmr-9-1-3

Abstract

Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC.

Keywords:
Hericium erinaceus polysaccharide Chinese herb immunity Dendritic cells

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