Article citationsMore >>

Banchereau, J. and R.M. Steinman, Dendritic cells and the control of immunity. Nature, 1998. 392(6673): p. 245-52.

has been cited by the following article:

Article

Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells

1#These authors contributed equally to this work.

2Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China


American Journal of Clinical Medicine Research. 2021, Vol. 9 No. 1, 10-13
DOI: 10.12691/ajcmr-9-1-3
Copyright © 2020 Science and Education Publishing

Cite this paper:
Lujiang Yi, Ye Jiang, Lu Yang. Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells. American Journal of Clinical Medicine Research. 2021; 9(1):10-13. doi: 10.12691/ajcmr-9-1-3.

Correspondence to: Lu  Yang, Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China. Email: nollen@163.com

Abstract

Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC.

Keywords