Case Study of Schizophrenia in A Young Adult Male

Mona Zein^1,

¹Department of Psychology, Arts and Humanities, The British University, Egypt

Cite this paper:
Mona Zein. Case Study of Schizophrenia in A Young Adult Male. American Journal of Applied Psychology. 2022; 10(1):20-30. doi: 10.12691/ajap-10-1-4

Abstract

This report presents a special case of a highly educated and intelligent patient diagnosed with simple schizophrenia and depression. This patient attended psychotherapy sessions regularly with the therapist (the author) which helped him to express his thoughts and ventilate his emotions. This report aims is to reinforce the importance of psychotherapy and family interventions in the management of a schizophrenic patient. The patient has adequate insight into the effects of schizophrenia on his self-reflection that have ended up leaving him frustrated with poor achievements in life. The patient’s symptoms were tracked using rehabilitative approaches and techniques. Counseling with the patient and his family completed 50 sessions treatment period. This resulted in a significant improvement in the patient's and family's functioning because they were able to recognize their problems, find appropriate solutions, and place them into action. The therapeutic experience of the schizophrenic patient is presented in this report.

Keywords:
schizophrenia case study psychotherapy psychosocial assessment personality intelligence psychopathology

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References:

[1]	Mendes Braga, M. E., Teixeira Batista, H. M., Brasil Sampaio Cardoso, M. A., Martins Cardoso Novais, M. D., Ferreira de Lima Silva, J. M., Moraes da Silva, F., Rodrigues Barros, R., Rodrigues Pinheiro, W., De Olim Câmara, J. A., Pinheiro Bezerra, I. M., & De Abreu, L. C. (2015). Schizoaffective disorder and depression. A case study of a patient from Ceará, Brazil. International Archives of Medicine.
[2]	Khokhar A & Sadeeqa S. (2017). Schizophrenia- A case study. Virology & Immunology Journal, 1(6).
[3]	Andlin-Sobocki, P., Jonsson, B., Wittchen, H., & Olesen, J. (2005). Cost of disorders of the brain in Europe. European Journal of Neurology, 12(s1), 1-27.
[4]	Jim van Os & Shitij Kapur. (2009). Schizophrenia. National library for medicine, 22; 374(9690): 635-45.
[5]	Pooler, C. (2009). Porth pathophysiology: Concepts of altered health states (2nd ed.). Lippincott Williams & Wilkins.
[6]	Souza, L. A., & Coutinho, E. S. (2006). Fatores associados a qualidade de Vida de pacientes com esquizofrenia. Revista Brasileira de Psiquiatria, 28(1), 50-58.
[7]	American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. (5th ed.).
[8]	Buzsáki, G., & Wang, X. (2012). Mechanisms of gamma oscillations. Annual Review of Neuroscience, 35(1), 203-225.
[9]	Andreasen, N. C. (1999). Understanding the causes of schizophrenia. The New England Journal of Medicine, 340(8), 645-647.
[10]	Okasha A. (2000). Mental health in the Middle East: An Egyptian perspective, Clinical Psychology Journal, 19(8): 917-33.
[11]	Laruelle, M. (2014). Schizophrenia: From dopaminergic to glutamatergic interventions. Current Opinion in Pharmacology, 14, 97-102.
[12]	Stępnicki, P., Kondej, M., & Kaczor, A. A. (2018). Current concepts and treatments of schizophrenia. Molecules, 23(8), 2087.
[13]	Ayuk-Egbe PB, Hogue VW. (2001). Comprehensive Pharmacy Review. American Journal of Pharmaceutical Education, 65(3): p 303.
[14]	Das, B., & Borbora, S. A. (2017). A case report of schizophrenia with severe disability: The eclectic family therapy approach. Open Journal of Psychiatry & Allied Sciences, 8(1), 91.
[15]	Claxton, M., Onwumere, J., & Fornells-Ambrojo, M. (2017). Do family interventions improve outcomes in early psychosis? A systematic review and meta-analysis. Frontiers in Psychology, 8.
[16]	Torrey, E. F. (2014). Surviving schizophrenia: A family manual (6th ed.). HarperCollins.
[17]	van Os, J., & Kapur, S. (2009). Schizophrenia. Lancet (London, England), 374(9690), 635-645.
[18]	Cunill, R., Castells, X., & Simeon, D. (2008). Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia. The Journal of Clinical Psychiatry, 70(1), 70-82.
[19]	Aguiar, C. C., Alves, C. D., Rodrigues, F. A., Barros, F. W., Sousa, F. C., Vasconcelos, S. M., & Macedo, D. S. (2010). Esquizofrenia: Uma doença inflamatória? Jornal Brasileiro de Psiquiatria, 59(1), 52-57.
[20]	Videbeck, S.L. (2012). Enfermagem em saúde mental e psiquiatria. (5.ed), Porto Alegre: Artmed.
[21]	Spring, B., & Zubin, J. (1977). Reaction time and attention in schizophrenia: A comment on K. H. Nuechterlein's critical evaluation of the data and theories*. Schizophrenia Bulletin, 3(3), 437-444.
[22]	McCay, E., Ryan, K., & Amey, S. (1996). Mitigating engulfment: Recovering from a first episode of psychosis. Journal of Psychosocial Nursing and Mental Health Services, 34(11), 40-44.
[23]	Fleck, M. P., Lima, A. F., Louzada, S., Schestasky, G., Henriques, A., Borges, V. R., & Camey, S. (2002). Associação entre sintomas depressivos E funcionamento social Em cuidados primários a saúde. Revista de Saúde Pública, 36(4), 431-438.
[24]	Karamatskos, E., Mulert, C., Lambert, M., & Naber, D. (2012). Subjective well-being of patients with schizophrenia as a target of drug treatment. Current Pharmaceutical Biotechnology, 13(8), 1490-1499.
[25]	TYRER, P., MULDER, R., CRAWFORD, M., NEWTON-HOWES, G., SIMONSEN, E., NDETEI, D., KOLDOBSKY, N., FOSSATI, A., MBATIA, J., & BARRETT1, B. (2010, February). Personality disorder: A new global perspective.
[26]	Cardoso, C. S., Caiaffa, W. T., Bandeira, M., Siqueira, A. L., Silva, J. T., & Fonseca, J. O. (2007). Depressão Na esquizofrenia: Prevalência E relação com a qualidade de Vida. Cadernos de Saúde Pública, 23(9), 2035-2048.
[27]	Andreasen, N. C., Carpenter, W. T., Kane, J. M., Lasser, R. A., Marder, S. R., & Weinberger, D. R. (2005). Remission in schizophrenia: Proposed criteria and rationale for consensus. American Journal of Psychiatry, 162(3), 441-449.
[28]	Opare-Addo, M. N., Mensah, J., & Aboagye, G. O. (2020). A case of schizophrenia in a young male adult with no history of substance abuse: Impact of clinical pharmacists’ interventions on patient outcome. Case Reports in Psychiatry, 1-5.
[29]	Haddad PM, Sharma SG. (2007). adverse effects of atypical antipsychotics: differential risk and clinical implications. CNS Drugs. 21(11): 911-36.
[30]	Shean, G. D. (2013). Understanding and treating schizophrenia: Contemporary research, theory, and practice (1st ed.). Routledge.
[31]	Liberman, R. P., & Kopelowicz, A. (2005). Recovery from schizophrenia: A criterion-based definition. Recovery in mental illness: Broadening our understanding of wellness, 101-129.
[32]	Jackson, C., Baggott, E., Bernard, M., Clutterbuck, R., Ryles, D., & Turner, E. (2019). Recovering from a first episode of psychosis: An integrated approach to early intervention (1st ed.). Routledge.
[33]	Onwumere, J., Smith, B., & Kuipers, E. (2010). Families and psychosis. Principles of Social Psychiatry, 103-116.
[34]	Lloyd, J., Lloyd, H., Fitzpatrick, R., & Peters, M. (2017). Treatment outcomes in schizophrenia: Qualitative study of the views of family carers. BMC Psychiatry, 17(1).
[35]	Chudzicka-Czupała, A., & Zalewska-Łunkiewicz, K. (2020). Subjective well-being, general self-efficacy and coping with stress in former psychiatric patients preparing for the peer support role: An exploratory study. Health and Quality of Life Outcomes, 18(1).
[36]	Bornheimer, L. A. (2016). Moderating effects of positive symptoms of psychosis in suicidal ideation among adults diagnosed with schizophrenia. Schizophrenia Research, 176(2-3), 364-370.
[37]	Alanen, Y. O. (2018). Treatment of schizophrenia and society. Schizophrenia, 237-257.
[38]	Melle, I., & Dazzan, P. (2014). Childhood trauma as risk factor in psychotic disorders – in search of mechanisms. Schizophrenia Research, 153, S43.
[39]	Matheson, S. L., Kariuki, M., Green, M. J., Dean, K., Harris, F., Tzoumakis, S., Tarren-Sweeney, M., Brinkman, S., Chilvers, M., Sprague, T., Carr, V. J., & Laurens, K. R. (2016). Effects of maltreatment and parental schizophrenia spectrum disorders on early childhood social-emotional functioning: A population record linkage study. Epidemiology and Psychiatric Sciences, 26(6), 612-623.
[40]	Gold, S. N., & Elhai, J. D. (2018). Trauma and serious mental illness (1st ed.). Routledge.
[41]	Popovic, D., Schmitt, A., Kaurani, L., Senner, F., Papiol, S., Malchow, B., Fischer, A., Schulze, T. G., Koutsouleris, N., & Falkai, P. (2019). Childhood trauma in schizophrenia: Current findings and research perspectives. Frontiers in Neuroscience, 13.
[42]	Mørkved, N., Johnsen, E., Kroken, R., Gjestad, R., Winje, D., Thimm, J., Fathian, F., Rettenbacher, M., Anda, L., & Løberg, E. (2020). Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders. Schizophrenia Research: Cognition, 21, 100179.
[43]	Morton, C. (2021). Childhood schizophrenia: Medical treatment, care and love for schizophrenia children.
[44]	Norman, R. M., Malla, A. K., Manchanda, R., & Townsend, L. (2005). Premorbid adjustment in first-episode schizophrenia and schizoaffective disorders: A comparison of social and academic domains. Acta Psychiatrica Scandinavica, 112(1), 30-39.
[45]	Rinaldi, R., & Lefebvre, L. (2016). Goal-directed behaviors in patients with schizophrenia: Concept relevance and updated model. Psychiatry and Clinical Neurosciences, 70(9), 394-404.
[46]	Bhalla, I. P., Stefanovics, E. A., & Rosenheck, R. A. (2018). Mental health multimorbidity and poor quality of life in patients with schizophrenia. Schizophrenia Research, 201, 39-45.
[47]	Moskowitz, A., Dorahy, M. J., & Schäfer, I. (2019). Psychosis, trauma and dissociation: Evolving perspectives on severe psychopathology. John Wiley & Sons.
[48]	Kapellerova, O. (2008). 124 – Recollection of bullying at school by people with diagnosis of schizophrenia. Schizophrenia Research, 98, 84.
[49]	Brott, L. (2006). Bizarre behavior (Schizophrenia). Essential Family Medicine, 678-683.
[50]	Rosenbaum, B. (2005). Psychosis and the structure of homosexuality: Understanding the pathogenesis of schizophrenic states of mind. The Scandinavian Psychoanalytic Review, 28(2), 82-89.
[51]	Bolton, S., & Sareen, J. (2011). Sexual orientation and its relation to mental disorders and suicide attempts: Findings from a nationally representative sample. The Canadian Journal of Psychiatry, 56(1), 35-43.
[52]	Robert Dole. (2020). Daniel Paul Schreber’s homosexuality and schizophrenia. Journal of Literature and Art Studies, 10(6).
[53]	Robert Dole. (2020). Emile Nelligan’s homosexuality and schizophrenia. Journal of Literature and Art Studies, 10(4).
[54]	Newton-Howes, G., & Marsh, R. (2012). Personality dysfunction and social functioning in schizophrenia. Personality and Mental Health, 7(2), 114-121.
[55]	Tadger, S., Baruch, Y., & Barak, Y. (2008). Symptomatic remission in elderly schizophrenia patients treated with long-acting risperidone. International Psychogeriatrics, 20(06), 1245.
[56]	Stanghellini, G. (2016). Abnormal time experience, bizarre delusions and verbal-acoustic hallucinations in schizophrenia. European Psychiatry, 33(S1), S32-S32.
[57]	Khandwala, P., Desai, D., Patel, G., & Rengan, R. (2021). Bizarre behaviors: Autoimmune encephalitis masquerading as a psychiatric syndrome. Chest, 160(4), A727.
[58]	Anderson, J., Westwick, J., & Anderson, J. (2016). “More alike than different”: Learning about diversity from people with disabilities. Communication Teacher, 30(3), 159-164.
[59]	Dauvermann, M. R., & Donohoe, G. (2019). The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder - A systematic review. Schizophrenia Research: Cognition, 16, 1-11.
[60]	Whiskey, E., O’Flynn, D., & Taylor, D. (2018). Clozapine, HIV and neutropenia: A case report. Therapeutic Advances in Psychopharmacology, 8(12), 365-369.
[61]	Levin, R. (2018). Successful drug-free psychotherapy for schizophrenia (1st ed.). Routledge.
[62]	Torrey, E. F. (2006). Prostate cancer and schizophrenia. Urology, 68(6), 1280-1283.
[63]	Raviv, G., Laufer, M., Baruch, Y., & Barak, Y. (2014). Risk of prostate cancer in patients with schizophrenia. Comprehensive Psychiatry, 55(7), 1639-1642.
[64]	Ge, F., Huo, Z., Liu, Y., Du, X., Wang, R., Lin, W., Wang, R., Chen, J., Lu, Y., Wen, Y., Cao, H., Shang, S., Eftekhar, M., & Gu, D. (2022). Association between schizophrenia and prostate cancer risk: Results from a pool of cohort studies and mendelian randomization analysis. Comprehensive Psychiatry, 115, 152308.
[65]	James, W. (2012). Substance abuse comorbidity in schizophrenia. Pharmacological and Psychosocial Treatments in Schizophrenia, Third Edition, 107-118.
[66]	Ding, J. B., & Hu, K. (2021). Cigarette smoking and schizophrenia: Etiology, clinical, pharmacological, and treatment implications. Schizophrenia Research and Treatment, 2021, 1-8.
[67]	Hor, K., & Taylor, M. (2010). Review: Suicide and schizophrenia: a systematic review of rates and risk factors. Journal of Psychopharmacology, 24(4_suppl), 81-90.
[68]	Helleberg, M., Pedersen, M. G., Pedersen, C. B., Mortensen, P. B., & Obel, N. (2015). Associations between HIV and schizophrenia and their effect on HIV treatment outcomes: A nationwide population-based cohort study in Denmark. The Lancet HIV, 2(8), e344-e350.
[69]	Ventriglio, A., Gentile, A., Bonfitto, I., Stella, E., Mari, M., Steardo, L., & Bellomo, A. (2016). Suicide in the early stage of schizophrenia. Frontiers in Psychiatry, 7.
[70]	Lincoln, S. H., Norkett, E., Graber, K., Tembulkar, S., Morelli, N., Gonzalez-Heydrich, J., & D'Angelo, E. (2017). Suicidal behaviors in children and adolescents with psychotic disorders. Schizophrenia Research, 179, 13-16.
[71]	Sher, L., & Kahn, R. S. (2019). Suicide in schizophrenia: An educational overview. Medicina, 55(7), 361.
[72]	Sewell, D. D. (1996). Schizophrenia and HIV. Schizophrenia Bulletin, 22(3), 465-473.
[73]	Jackson, H. J., & McGorry, P. D. (2009). The recognition and management of early psychosis: A preventive approach (2nd ed.). Cambridge University Press.
[74]	Zanarini, M. C., Skodol, A. E., Bender, D., Dolan, R., Sanislow, C., Schaefer, E., Morey, L. C., Grilo, C. M., Shea, M. T., McGlashan, T. H., & Gunderson, J. G. (2000). The collaborative longitudinal personality disorders study: Reliability of Axis I and II diagnoses. Journal of Personality Disorders, 14(4), 291-299.
[75]	Mueser, K. T., & Jeste, D. V. (2011). Clinical handbook of schizophrenia. Guilford Press. New York London.
[76]	Rus-Calafell, M., Caqueo-Urízar, A., Urzúa, A., Escudero, J., & Gutiérrez-Maldonado, J. (2015). The role of family therapy in the management of schizophrenia: Challenges and solutions. Neuropsychiatric Disease and Treatment, 11(145-151).
[77]	Pfammatter et al., 2006 Pfammatter M, Junghan UM, Brenner HD. (2006). Efficacy of psychological therapy in schizophrenia: conclusions from meta-analyses. Schizophr Bull. 32 (Suppl 1): S64-80.
[78]	Karon, B. P., & VandenBos, G. R. (1981). Psychotherapy of schizophrenia: The treatment of choice. Rowman & Littlefield.
[79]	Auerhahn, N. C., & Moskowitz, M. B. (1984). Merger fantasies in individual inpatient therapy with schizophrenic patients. Psychoanalytic Psychology, 1(2), 131-148.
[80]	Kernberg, O. F. (1986). Institutional problems of psychoanalytic education. Journal of the American Psychoanalytic Association, 34(4), 799-834.
[81]	Dickman, S. (1987). Munich: Expensive survival. Nature, 328(6133), 753-753.
[82]	Strean, H. S. (1988). Effects of childhood sexual abuse on the psychosocial functioning of adults. Social Work, 33(5), 465-467.
[83]	Hogarty, G. E., Greenwald, D., Ulrich, R. F., Kornblith, S. J., DiBarry, A. L., Cooley, S., Carter, M., & Flesher, S. (1997). Three-year trials of personal therapy among schizophrenic patients living with or independent of family, II: Effects on adjustment of patients. American Journal of Psychiatry, 154(11), 1514-1524.
[84]	Rosenbaum, B., Harder, S., Knudsen, P., Køster, A., Lindhardt, A., Lajer, M., Valbak, K., & Winther, G. (2012). Supportive psychodynamic psychotherapy versus treatment as usual for first-episode psychosis: Two-year outcome. Psychiatry: Interpersonal and Biological Processes, 75(4), 331-341.
[85]	Frosh, S. (1999). The politics of psychoanalysis: An introduction to freudian and post-freudian theory (2nd ed.). NYU Press.
[86]	Gottdiener, W. H. (2006). Individual psychodynamic psychotherapy of schizophrenia: Empirical evidence for the practicing clinician. Psychoanalytic Psychology, 23(3), 583-589.
[87]	Brian Martindale & Alison Summers, 2018 Martindale, B., & Summers, A. (2013). The psychodynamics of psychosis. Advances in Psychiatric Treatment, 19(2), 124-131.
[88]	Malmberg, L., Fenton, M., & Rathbone, J. (2001). Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness. Cochrane Database of Systematic Reviews, 2012(2).
[89]	Karon, B. P. (2008). Psychotherapy of schizophrenia works. Pragmatic Case Studies in Psychotherapy, 4(1), 55-61.
[90]	Steggles, G. R. (2015). Stages in the psychological resolution of schizophrenia. Frontiers in Psychology, 6.
[91]	Morrison .R Fraser. (2009). a circuit judge. Who's Who?
[92]	Trepper, T. S., & Shean, G. D. (2013). Understanding and treating schizophrenia: Contemporary research, theory, and practice. Routledge.
[93]	Zimmermann, G., Favrod, J., Trieu, V., & Pomini, V. (2005). The effect of cognitive behavioral treatment on the positive symptoms of schizophrenia spectrum disorders: A meta-analysis. Schizophrenia Research, 77(1), 1-9.
[94]	Turkington, D., Sensky, T., Scott, J., Barnes, T. R., Nur, U., Siddle, R., Hammond, K., Samarasekara, N., & Kingdon, D. (2008). A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: A five-year follow-up. Schizophrenia Research, 98 (1-3), 1-7.
[95]	Turkington, D. (2012). Cognitive behavior therapy for positive and negative symptoms of schizophrenia. Schizophrenia Research, 136, S31.
[96]	Morrison, A. P. (2019). Should people with psychosis be supported in choosing cognitive therapy as an alternative to antipsychotic medication: A commentary on current evidence. Schizophrenia Research, 203, 94-98.
[97]	Bebbington, P., & Kuipers, E. (2011). Schizophrenia and psychosocial stresses. Schizophrenia, 613-636.
[98]	Castle, D., Copolov, D. L., Wykes, T., & Mueser, K. T. (2011). Psychosocial and pharmacological treatments for schizophrenia. Effective Treatments in Psychiatry, 152-158.
[99]	Bellack, A. S. (2001). Psychosocial treatment in schizophrenia. Dialogues in Clinical Neuroscience, 3(2), 136-137.
[100]	Liberman, R. P., & Kopelowicz, A. (2005). Recovery from schizophrenia: A concept in search of research. Psychiatric Services, 56(6), 735-742.
[101]	Kurtz, M., & Mueser, K. (2008). A meta-analysis of controlled research on social skills training for schizophrenia. Schizophrenia Research, 98, 56-57.
[102]	Bighelli, I., Rodolico, A., García-Mieres, H., Pitschel-Walz, G., Hansen, W., Schneider-Thoma, J., Siafis, S., Wu, H., Wang, D., Salanti, G., Furukawa, T. A., Barbui, C., & Leucht, S. (2021). Psychosocial and psychological interventions for relapse prevention in schizophrenia: A systematic review and network meta-analysis. The Lancet Psychiatry, 8(11), 969-980.
[103]	Dixon, L., Adams, C., & Lucksted, A. (2000). Update on family Psychoeducation for schizophrenia. Schizophrenia Bulletin, 26(1), 5-20.
[104]	Lukens, E. P., & McFarlane, W. R. (2004). Psychoeducation as evidence-based practice: Considerations for practice, research, and policy. Brief Treatment and Crisis Intervention, 4(3), 205-225.
[105]	Lucksted, A., & Dixon, L. (1999). Mental Health Services Research, 1(4), 223-230.
[106]	Xia, Y., & Et al., E. A. (2011). ChemInform abstract: Synthesis and SAR of novel Benzoxaboroles as a new class of β-lactamase inhibitors. ChemInform, 42(34), no-no.
[107]	Harvey, C. (2018). Family psychoeducation for people living with schizophrenia and their families. BJPsych Advances, 24(1), 9-19.
[108]	Sarkhel, S., Singh, O., & Arora, M. (2020). Clinical practice guidelines for Psychoeducation in psychiatric disorders general principles of Psychoeducation. Indian Journal of Psychiatry, 62(8), 319.
[109]	Hubbard, R. L., Craddock, S. G., Flynn, P. M., Anderson, J., & Etheridge, R. M. (1997). Overview of 1-year follow-up outcomes in the Drug Abuse Treatment Outcome Study (DATOS). Psychology of Addictive Behaviors, 11(4), 261-278.
[110]	Miller, W., & Rollnick, S. (2003). Motivational interviewing: Preparing people for change, 2nd ed. Journal for Healthcare Quality, 25(3), 46.
[111]	Dabbo, S., & Dabbo, N. (2010). Motivational interviewing: Preparing people for change. University of Toronto Medical Journal, 87(2).
[112]	Engler, P. A., Ramsey, S. E., & Smith, R. J. (2013). Alcohol use of diabetes patients: the need for assessment and intervention. Acta diabetologica, 50(2), 93-99.
[113]	Daley, D. C., & Maccarelli, L. (2014). Psychosocial interventions for substance use disorders. In A. Douaihy & D. C. Daley (Eds.), Substance use disorders (pp. 213-246). Oxford University Press.
[114]	Hettema, J., Steele, J., & Miller, W. R. (2005). Motivational interviewing. Annual Review of Clinical Psychology, 1(1), 91-111.
[115]	Jhanjee S. (2014). Evidence-Based Psychosocial Interventions in Substance Use. Indian Journal of Psychological Medicine, 36(2):112-118.
[116]	Darke, S. (2016). Psychosocial interventions for mental and substance use disorders: A framework for establishing evidence-based standards Mary Jane England, Adrienne Stith butler & Monica L. Gonzalez (Editors); Committee on developing evidence-based standards for PSYCHOSO. Drug and Alcohol Review, 35(4), 503-503.
[117]	Haddock, G., Barrowclough, C., Tarrier, N., Moring, J., O'Brien, R., Schofield, N., Quinn, J., Palmer, S., Davies, L., Lowens, I., McGovern, J., & Lewis, S. (2003). Cognitive-behavioural therapy and motivational intervention for schizophrenia and substance misuse. British Journal of Psychiatry, 183(5), 418-426.
[118]	Thompson, P. (2021). The application of psychosocial interventions in practice. Schizophrenia, (1ed), 75-98.
[119]	Agosti, V., & Levin, F. R. (2006). The effects of alcohol and drug dependence on the course of depression. American Journal on Addictions, 15(1), 71 75.
[120]	Kranzler, H. R., & Soyka, M. (2018). Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review. JAMA, 320(8), 815-824.
[121]	Daley, D. C., & Douaihy, A. B. (2019). Managing substance use disorder: Practitioner guide (3rd ed.). Oxford University Press, USA.
[122]	McHugh, R. K., & Weiss, R. D. (2019). Alcohol Use Disorder and Depressive Disorders. Alcohol research: current reviews, 40(1), arcr. v40.1.01.
[123]	Andrade, A. L., Micheli, D. D., Silva, E. A., Lopes, F. M., Pinheiro, B. D., & Reichert, R. A. (2021). Psychology of substance abuse: Psychotherapy, clinical management and social intervention. Springer Nature.
[124]	Sidossis, L. S., & Kales, S. N. (2022). Textbook of lifestyle medicine. John Wiley & Sons.
[125]	Lally, J., Maloudi, S., Krivoy, A., & Murphy, K. C. (2019). Simple schizophrenia. Journal of Nervous & Mental Disease, 207(9), 721-725.
[126]	Kantrowitz JT. (2017). Managing Negative Symptoms of Schizophrenia: How Far Have We Come? CNS Drugs, 31(5): 373-388.
[127]	Bitter, I. (2020). Managing negative symptoms of schizophrenia. Oxford University Press.
[128]	Smulevich, A., & Romanov, D. (2020). Long-term course of negative symptoms in schizophrenia. Managing Negative Symptoms of Schizophrenia, 39-50.
[129]	Singh S.P., Kulhara P. (1991). Simple schizophrenia: patients in search of a diagnosis. Indian J Psychiatry, 33(4): 266-70.
[130]	Serra-Mestres, J., Gregory, C. A., Tandon, S., Stansfield, A. J., Kemp, P. M., & McKenna, P. J. (2000). Simple schizophrenia revisited: A clinical, Neuropsychological, and neuroimaging analysis of nine cases. Schizophrenia Bulletin, 26(2), 479-493.
[131]	Moini, B., & Levenson, J. L. (2009). A forgotten diagnosis: Simple schizophrenia in a patient with breast cancer. Psychosomatics, 50(1), 87-89.
[132]	O’Brien, D., & Macklin, J. (2014). Late onset simple schizophrenia. Scottish Medical Journal, 59(1), e1-e3.
[133]	Agarwal, V., Maheshwari, S., Agarwal, V., & Kalra, I. D. (2016). Simple schizophrenia remains a complicated diagnosis. Journal of Nervous & Mental Disease, 204(1), 5760.
[134]	Nascimento, S., Caldas, I., Reis, J., & Cortez Pinto, L. (2019). Late-onset schizophrenia – A case report.
[135]	Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2022). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia Research, 239, 92-94.
[136]	Berzoff, J., Flanagan, L. M., & Hertz, P. (2008). Inside out and outside in: Psychodynamic clinical theory and psychopathology in contemporary multicultural contexts. Jason Aronson.
[137]	Bartlett, J. (2014). Childhood-onset schizophrenia: what do we really know?. Journal of Health Psychology and behavioral medicine, 2(1):735-747.
[138]	Seeman, M. V. (2016). Solitude and schizophrenia. Psychosis, 9(2), 176-183.
[139]	Semple, D., & Smyth, R. (2019). Oxford handbook of psychiatry (4th ed.). Oxford University Press.
[140]	Smelror, R. E., Rund, B. R., Lonning, V., Jørgensen, K. N., Wedervang-Resell, K., Andreassen, O. A., Ueland, T., Myhre, A. M., & Agartz, I. (2020). Negative and disorganized symptoms mediate the relationship between verbal learning and global functioning in adolescents with early-onset psychosis. European Child & Adolescent Psychiatry, 29(12), 1693-1703.
[141]	Fett A.J., Velthorst E., Reichenberg A., Ruggero C.J., Callahan J.L., Fochtmann L.J., Carlson G.A., Perlman G., Bromet E.J., Kotov R. (2020). Long-term Changes in Cognitive Functioning in Individuals with Psychotic Disorders: Findings from the Suffolk County Mental Health Project. JAMA Psychiatry, 1; 77(4): 387-396.
[142]	Stevens, J. R., Prince, J. B., Prager, L. M., & Stern, T. A. (2014). Psychotic disorders in children and adolescents: a primer on contemporary evaluation and management. The primary care companion for CNS disorders, 16(2), PCC.13f01514.
[143]	Gregory, C. A., McKenna, P. J., & Hodges, J. R. (1998). Dementia of frontal type and simple schizophrenia: Two sides of the same coin? Neurocase, 4(1), 1-6.
[144]	Stankovska, G., & Memedi, I. (2020). Positive and negative symptoms, cognitive deficits and antipsychotic treatment in schizophrenic patients. European Neuropsychopharmacology, 40, S460.
[145]	Martínez Serrano J, Medina Garrido ML, Consuegra Sánchez R, Del Cerro Oñate M, López-Mesa JL, González Matás J. (2012). In defense of the diagnosis of simple schizophrenia: reflections on a case presentation, Rev Psiquiatr Salud Ment, 5(1): 53-62.
[146]	Kaneko & Koichi. (2018). Negative Symptoms and Cognitive Impairments in Schizophrenia: Two Key Symptoms Negatively Influencing Social Functioning.” Yonago acta med, 61(2), 91-102.
[147]	Schultze-Lutter, F. (2020). Basic symptoms in deficit states and their relation to negative symptoms. In I. Bitter (Ed.), Managing negative symptoms of schizophrenia (pp. 19-37). Oxford University Press.
[148]	Memedi & Miloseva. (2020). Cognitive deficit, positive and negative symptoms in patients with schizophrenia, Medical Journal MEDICUS, 25 (3). pp. 399-404.
[149]	Peng, X., Hei, G., Yang, Y., Liu, C., Xiao, J., Long, Y., Huang, J., Zhao, J., & Wu, R. (2021). The association between cognitive deficits and clinical characteristic in first-episode drug naive patients with schizophrenia. Frontiers in Psychiatry, 12.
[150]	Pradhan, B., Pinninti, N., & Rathod, S. (2016). Brief interventions for psychosis: A clinical compendium. Springer.
[151]	Haram, A., Fosse, R., Jonsbu, E., & Hole, T. (2019). Impact of psychotherapy in psychosis: A retrospective case control study. Frontiers in Psychiatry, 10.
[152]	Gergov, V., Milic, B., Löffler-Stastka, H., Ulberg, R., Vousoura, E., & Poulsen, S. (2022). Psychological interventions for young people with psychotic disorders: A systematic review. Frontiers in Psychiatry, 13.