Application of Binary Logistic Regression in Assessing Risk Factors Affecting the Prevalence of Toxoplasmosis

Mutangi Kudakwashe^1, and Kasim Mohammed Yesuf²

¹Department of Mathematics, Harare Institute of Technology, P O box BE277, Belvedere, Harare, Zimbabwe

²Kasim Mohammed Yesuf, Department of Statistics, University of Gondar, P O Box 196, Gondar, Ethiopia

Cite this paper:
Mutangi Kudakwashe and Kasim Mohammed Yesuf. Application of Binary Logistic Regression in Assessing Risk Factors Affecting the Prevalence of Toxoplasmosis. American Journal of Applied Mathematics and Statistics. 2014; 2(6):357-363. doi: 10.12691/ajams-2-6-1

Abstract

Toxoplasmosis is a parasitic disease caused by the protozoan parasite Toxoplasma Gondii (T.gondii). The parasite infects warm-blooded animals among them humans especially those whose immunity has been compromised. The transmission mode of the parasite vary from living in unhygienic conditions, contact with cat faeces to contact with raw meat or the practice of raw meat eating, such as commonly practiced in Ethiopia. Binary logistic regression was used to determine the risk factors affecting the prevalence of toxoplasmosis in HIV/AIDS patients. Significant risk factors were detected using the Wald and the likelihood ratio tests. The model selected was then subjected to diagnostic checks to assess its fitness using the Hosmer and Lemeshow test as well as the Pearson, and deviance goodness of fit tests. The results showed that patients living under unhygienic conditions, aged patients, illiterate and less educated patients were mostly affected by toxoplasmosis. There was more prevalence in urban areas than in rural areas possibly due to the high density of people in urban areas.

Keywords:
logistic regression toxoplasmosis risk factors prevalence diagnostic tests HIV/AIDS

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References:

[1]	Agresti, A, Categorical data analysis, Gainesville, Florida, 2002
[2]	Alemtsehai, A. And Eshetu, W, Association of HIV infection with some selected factors and modelling the chance of contracting HIV: The case of Hawassa and its surrounding. Journal of Ethiopian Statistical Association, 15. 27-48. 2006
[3]	Bresciani, K.D.S, Galvao, A.L.B, de Vsconcellos, A.L, Soares, J.A, de Matos, L.V.S, Pierucci, J.C, Neto, L.S, Rodrigues, T.O, Navarro, I.T, Gomes, J.F and da Costa, A.J, Relevant aspects of human toxoplasmosis. Research Journal of Infectious diseases. 2013. [online]. Available: http://www.hoajonline.com/journals/pdf/2052-5958-1-7.pdf more details.
[4]	Buve, A., Carael, M. and Hayes, R.J, Multi-center study on factors determining differences in rate of spread of HIV in sub-saharan Africa: Methods and prevalence of HIV infection. AIDS 15 (4). 5-14. 2001.
[5]	Ethiopia Demographic Health Survey (EDHS). Central statistical agency, Addis Ababa, Ethiopia. September 2006.
[6]	Fong, M.Y, Wong, K.T, Rohela, M, Tan, L.H, Adeeba, K., Lee, Y.Y, and Lau, Y.L, unusual manifestation of cutaneous toxoplasmosis in an HIV-positive patient. Tropical biomedicine, 27 (3). 447-450. 2010.
[7]	Gebremedhin, E.Z, Abebe, A.H, Tessema, T.S, Tullu,K.D, Medhin, G, Vitale, M, Di Marco, V, Cox, E and Dorny, P, Sero-epidemiology of toxoplasma gondii infection in women of child bearing age in central Ethiopia. BMC infectious diseases, 13: 101, February 2013. [online]. Available: http://www.biomedcentral.com/1471-2334/13/101. [Accessed July. 25, 2014].
[8]	Guebre-Xabier, M, Nurilign, A, Gebre-Hiwot, A, Hailu, A, sissay, Y, Getachew, E, Frommel, D, Sero-epidemiological survey of toxoplasma gondii infection in Ethiopia. Ethiopian Medical Journal, 31 (3). 201-208. 1993.
[9]	Hosmer, D.W, and Lemeshow, S, Applied logistic regression 2nd edition, John wiley & Sons Inc, New York, 2000.
[10]	Jara, M, Hsu, H.W, Eaton, R.B, Demaria, A.Jr, Epidemiology of congenital toxoplasmosis identified by population based newborn screening in Massachusetts. Paediatr infect Disease Journal, 20 (12). 1132-5. 2001.
[11]	Jayawardena, S, Singh, S, Burzyantseya, O and Clarke, H, Cerebral toxoplasmosis in adult patients with HIV infection. Hospital Physician, 44 (7). 17-24. 2008.
[12]	Luft,B.J,and Remmington, J.S, AIDS commentary. Toxoplasmosis encephalitis. Journal of infectious Diseases, 157 (1). 1-6.1988.
[13]	Njunda, A.L, Assob, J.C.N, Nsagha, D.S, Kamga, H.L, nde, P.F, and Yugah, V.C, Seroprevalence of toxoplasma gondii infection among pregnant women in Cameroon. Journal of public health in Africa, 2 (e24). 98-101. 2011.
[14]	Ogoina, D, Onyemelukwe, G.C, Musa, B.O, and Obiako, R.O, Seroprevalence of IgG and IgM antibodies to toxoplasma infection in healthy and HIV positive adults from Northern Nigeria. Journal Infect dev ctries, 7 (5). 398-403. 2013.
[15]	Okwuzu, J.O, Odunukwe, N.N, Ezechi, O.C, Gbajabiamila, T.A, Musa, A.Z, Ezeobi, P.M, Oke,B.A, Somefun,T, Okoye, R, Onyeitu, C.C, Adetunji, M, and Otubanjo, A.O, Toxoplasma gondii infection in HIV/AIDS: prevalence and risk factors. African Journal of clinical and Experimental microbiology, 15 (2). 97-102. 2014.
[16]	Techalew, S, Mekashaw, T, Endale, T, Belete, T and Ashenafi, T, Seroprevalence of latent Toxoplasma gondii infection among HIV-infected and HIV-uninfected people in Addis Ababa, Ethiopia: A comparative cross sectional study. BMC Research Notes, 2: 13. 2009. [online] Available: http://www.biomedcentral.com/1756-0500/2/213. [accessed July. 31, 2014].
[17]	Verheij, R.A, Explaining urban-rural variations in health: A review of interactions between individual and environment. Social Science and Medicine, 42 (6). 923-35. 1996.
[18]	Wanachiwanawin, D, Sutthent, R, Chokephaibulkit, K, Mahakittikun, V, Ongrotchanakun, J and Monkong, N, Toxoplasma gondii antibodies in HIV and non-HIV infected Thai pregnant women. Asia and Pacific Journal of allergy and immunology, 19 (4). 291-293. 2001
[19]	Williams, C.C, and Windebank, J, helping people to help themselves: policy lessons from a study of deprived urban neighbourhoods in Southampton. Journal of Social Science Policy, 29 (3). 355-373. 2000.
[20]	Zemene, E, Yewhalaw, D, Abera, S, Belay, T, Samuel, A, and Zeynudin, A, Seroprevalence of toxoplasma gondii and associated risk factors among pregnant women in Jimma town, South Western Ethiopia. BMC infectious diseases, 12: 337. December 2012. [Online]. Available: http://biomedcentral.com/1471-2334/12/337 [Accessed July. 25, 2014].
[21]	Zuffrey, J, Sugar, A, Rudaz, P, Bille, J, Glauser, M.P, and Chave, J.P, Prevalence of latent toxoplasma and serologic diagnosis of acute infection in HIV-positive patients. European Journal of Clinical Microbiology and Infectious Diseases, 12 (8). 591-5. 1993.