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Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. (2010) Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. Journal of Clinical Oncology, 28 (25), 3958-3964.

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Article

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

1Key Lab for Agro-products Processing and Quality Control of Nanchan City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China

2College of Animal Science and Technonlogy, Jiangxi Agricultural University, Nanchang, China


Journal of Food and Nutrition Research. 2014, Vol. 2 No. 9, 601-607
DOI: 10.12691/jfnr-2-9-12
Copyright © 2014 Science and Education Publishing

Cite this paper:
Li Nan, Ouyang Kehui, Cai Jiaoying, Yang Wuying, Wang Wenjun. Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice. Journal of Food and Nutrition Research. 2014; 2(9):601-607. doi: 10.12691/jfnr-2-9-12.

Correspondence to: Wang  Wenjun, Key Lab for Agro-products Processing and Quality Control of Nanchan City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China. Email: wwjun9999@sina.com

Abstract

Aloe flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg·BW simvastatin, 100, 200, 300 mg/kg·BW aloe flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-γ), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that aloe flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with aloe flavonoids, the gene expressions of HSL, PPARγ and ATGL expression enhanced, but the gene expression of FAS decreased when compared to the control group. In conclusion, our data showed that aloe flavonoids have potent hypolipemic and antioxidant activities.

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