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Jiao C, Chen W, Tan X, Liang H, Li J, Yun H, et al. Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9. J Ethnopharmacol. 2020; 247: 112256.

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Article

Antioxidant Capacity and Immune Regulation Properties of a Herbal Mixture Including Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum

1Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan

2Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan

3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan


Journal of Food and Nutrition Research. 2021, Vol. 9 No. 2, 73-78
DOI: 10.12691/jfnr-9-2-3
Copyright © 2021 Science and Education Publishing

Cite this paper:
Yung-Kai Lin, Wei-Chun Hu, Chi-Fu Chiang. Antioxidant Capacity and Immune Regulation Properties of a Herbal Mixture Including Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum. Journal of Food and Nutrition Research. 2021; 9(2):73-78. doi: 10.12691/jfnr-9-2-3.

Correspondence to: Chi-Fu  Chiang, Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan. Email: dofugood1205@outlook.com

Abstract

Many Chinese herbal medicines have been proven to have anti-inflammatory effects. Among them, edible and medicinal mushrooms are rich in a variety of physiologically active ingredients, which can enhance immunity and are good materials for the development of health foods. This article aims to investigate the beneficial effects of SOD Light, a herbal formula consisting of Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum, on anti-inflammation, antioxidant, and immune-modulation. SOD Light was able to inhibit ROS expression level and boost the SOD activity in PBMCs by 11% and 43.8%, respectively, as compared with the control group, and the significant improvement effect of the phagocytic activity of neutrophils was exhibited. Moreover, SOD Light also significantly enhanced the expression of the lymphocyte development-associated and adaptive immune-related genes (i.e., CD134, CD26, CD96, CD247, and IL-16). This study successfully unveils that the combination of S. crispa, A. pullulans, and G. lucidum was available for anti-oxidation, cytokines production, enhancement of T cell activation, and lymphocyte development in PBMCs, which implies that SOD Light are beneficial for immune modulation.

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