Pathophysiology may be defined as a hybrid fundamental science, focusing on changes in the body’s major functions during diseases, such as scurvy and other nutritional deficiencies. Mostly, it allows to understand the biological modifications triggering the illness-related manifestations. Thus, the aim of this study is to critically review the pathophysiological and clinical alterations of this metabolic disorder under various age groups (i.e., children, adults, and the elderly). Other vulnerable populations are revised too, for instance, individuals with malnutrition and (or) alcoholism, and diabetes mellitus. Nevertheless, the present work does not discuss in detail the mandatory vitamin C supplementation in scurvy.

adults, ascorbic acid, children, diabetes mellitus, metabolism, pathophysiology, signs