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International Journal of Clinical and Experimental Neurology
ISSN (Print): 2379-7789 ISSN (Online): 2379-7797 Website: https://www.sciepub.com/journal/ijcen Editor-in-chief: Zhiyou Cai, MD
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International Journal of Clinical and Experimental Neurology. 2014, 2(1), 8-15
DOI: 10.12691/ijcen-2-1-3
Open AccessReview Article

Lipocalin-2: a New Regulator of Non-Pathogen-Associated Neuroinflammation

Manoj Banjara1,

1Department of Biomedical Sciences, Texas Tech University HSC, Amarillo, Amarillo, TX

Pub. Date: September 18, 2014
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Cite this paper:
Manoj Banjara. Lipocalin-2: a New Regulator of Non-Pathogen-Associated Neuroinflammation. International Journal of Clinical and Experimental Neurology. 2014; 2(1):8-15. doi: 10.12691/ijcen-2-1-3

Abstract

Lipocalin is a family of small molecules transporting extracellular proteins. Lipocalin-2 (LCN2) is a member of the family that sequesters iron-bound bacterial siderophores. The well-accepted function of LCN2 protein is its anti-bacterial behavior, however, its role in iron regulation, cellular migration, death and morphology modulation have been speculated. Several reports have correlated the presence of LCN2 in the infected, injured and stressed brain, and its effect in neuronal and non-neuronal cell types in the central nervous system. This article reviews studies that demonstrated mechanisms and functions of LCN2 expression in inflammed brain (acute and chronic), particularly in non-pathogen-associated neuroinflammation. This review predicts that LCN2 can be an attractive target to reduce mortality and morbidity associated with uncontrollable neuroinflammation.

Keywords:
Lipocalin-2 neuroinflammation PAMPs DAMPs

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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