RISK FACTORS AND DIAGNOSTIC ROLE OF PLATELET-LYMPHOCYTE RATIO AND NEUTROPHIL-LYMPHOCYTE RATIO IN ACUTE AND CHRONIC DEEP VENOUS THROMBOSIS

Adekunle Emmanuel Alagbe^1, , John Ayodele Olaniyi² and Olayemi Atinuke Alagbe³

¹Department of Clinical Pathology, State University of Campinas, Campinas, Brazil.

²Department of Hematology, University College Hospital/University of Ibadan, Ibadan, Nigeria.

³Department of Radiology, LAUTECH Teaching Hospital, Osogbo, Nigeria.

Cite this paper:
Adekunle Emmanuel Alagbe, John Ayodele Olaniyi and Olayemi Atinuke Alagbe. RISK FACTORS AND DIAGNOSTIC ROLE OF PLATELET-LYMPHOCYTE RATIO AND NEUTROPHIL-LYMPHOCYTE RATIO IN ACUTE AND CHRONIC DEEP VENOUS THROMBOSIS. International Journal of Clinical and Diagnostic Research. 2019; 7(6):131-140. doi: 10.12691/ijcdr-7-6-2

Abstract

Increasing evidence suggests that inflammation underlies venous thrombosis. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are biomarkers for systemic inflammation, which can be obtained through complete blood count (CBC). The aim was to determine the pattern of NLR, PLR and risk factors for Deep Venous Thrombosis (DVT) in patients with Doppler ultrasound-diagnosed acute and chronic DVT. These ratios were correlated with the Wells scores of patients with DVT. This retrospective study was conducted in the Department of Hematology, University College Hospital, Ibadan, Nigeria, between July-December 2016. It comprised of all referred patients who had a unilateral or bilateral lower limb swelling and confirmed DVT. Risk factors for DVT, Wells score and hematological parameters of each patient were obtained from the patient´s records. NLR and PLR were derived from CBC (Complete Blood Count). Out of 55 DVT patients aged between 15 and 87 years, 33(60%) were females and 22(40%) were males. 85.5% of these patients had acute DVT. Among these, 55% had left lower limb DVT, only 12.5% had bilateral lower limb involvement, and most patients (92.7%) had proximal DVT. 98% of patients had a moderate or high DVT risk and immobilization was the commonest risk factor (70.9%). PLR was elevated more in acute than in chronic DVT patients (p=0.004), but NLR was not different. However, both ratios were positively correlated. This study emphasizes the reliability of Wells score in predicting DVT and suggests the use of PLR as a marker of acute DVT since it was markedly elevated in acute than chronic DVT. A large prospective study is recommended to verify our findings.

Keywords:
DVT risk factors neutrophil-lymphocyte ratio platelet-lymphocyte ratio inflammation Wells score.

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