HISTOLOGICAL AND IMMUNOHISTOLOGICAL CHANGES DURING THE EXPRESSION OF FOXO3A IN HUMAN BREAST CANCER TISSUES

Ranganathan Keerthana¹ and Pachiappan Perumal^1,

¹Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem-636011, Tamil Nadu

Cite this paper:
Ranganathan Keerthana and Pachiappan Perumal. HISTOLOGICAL AND IMMUNOHISTOLOGICAL CHANGES DURING THE EXPRESSION OF FOXO3A IN HUMAN BREAST CANCER TISSUES. International Journal of Clinical and Diagnostic Research. 2016; 4(1):9-15. doi: 10.12691/ijcdr-4-1-3

Abstract

Background & Objectives: Breast cancer is an aggressive cancer in females, worldwide and is the major cancer among Indian women. The cause of breast cancer includes environmental, genetic and hormonal factors. The present study is to analyse the expression of FOXO3a in Infiltrating Ductal carcinomas of breast cancer patients and corresponding normal tissues. Materials & methods: Formalin fixed paraffin embedded tissues of breast cancer and corresponding normal tissues of women, were included in this study. Expression of FOXO3a was analysed by IHC in relation to histology. Results: In Immunohistochemistry study FOXO3a was found to be expressed in breast cancer and its expression correlated with clinical and pathological parameters. Conclusions: FOXO3a expression showed a significant alteration in breast cancer patients.

Keywords:
Breast cancer FOXO3a Immunohistochemistry Markers

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