Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity

Aaron Lerner^{1, 2,} , Kai Prager² and Torsten Matthias²

¹Bruce Rappaport School of Medicine, Technion-Israel institute of Technology, Haifa, Israel

²Aesku.Kipp Institute, Wendelsheim, Germany

Cite this paper:
Aaron Lerner, Kai Prager and Torsten Matthias. Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity. International Journal of Celiac Disease. 2015; 3(2):72-74. doi: 10.12691/ijcd-3-2-11

Abstract

Transient anti transglutaminase2 and anti endomysial antibody elevation in systemic lupus erythematosus is fundamentally thought-provoking with respect to establishment of autoimmunity and its progression. Celiac disease and systemic lupus erythematosus are both relayed within the mosaic framework of autoimmunity. Transglutaminase2 is a multifunctional enzyme, involved in cell biology and survival and is one of the post translational modifiers of protein, enhancing autoimmunity. TG2 and its specific antibodies are heavily involved in celiac disease. TG2 is essential in clearance of apoptotic cells and experimentally participates in systemic lupus-like induction. However, the role of anti TG2 autoantibodies is far from being unraveled. Despite disappearance of these antibodies on gluten containing diet, in the present case, the boy is at risk of developing celiac disease in the future.

Keywords:
tissue transglutaminase anti-TG2 autoantibodies systemic lupus erythematosus celiac disease autoimmunity

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