American Journal of Microbiological Research
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American Journal of Microbiological Research. 2016, 4(2), 61-63
DOI: 10.12691/ajmr-4-2-3
Open AccessArticle

Study of Haptoglobin Phenotypes in Sudanese Diabetic Patients

Nafisa M. Osman1, , Hind A. Gasim Elseed2 and Atif A. Elagib1, 2

1Sudan Academy of Sciences, Council of Biological Sciences, New technology and Enviroments, Tropical Medcine Program Khartoum, Sudan

2Tropical Medicine Research Institute, National Cenre for Research

Pub. Date: April 21, 2016

Cite this paper:
Nafisa M. Osman, Hind A. Gasim Elseed and Atif A. Elagib. Study of Haptoglobin Phenotypes in Sudanese Diabetic Patients. American Journal of Microbiological Research. 2016; 4(2):61-63. doi: 10.12691/ajmr-4-2-3

Abstract

In this case – control study conducted during the period from February 2013 to January 2015, Haptoglobin phenotypes in diabetes patients has been investigated in 300 type 2 diabetic patients and 100 non diabetic healthy controls in Sudan. The samples were obtained from Elmotakmel diabetic center in Omdurman, Sudan and were categorized by their haptoglobin phenotypes using Polyacrylamide gel electrophoresis. The result of the study showed no significant difference in the distribution of haptoglobin phenotypes. Diabetic patients with Hp 2-2 phenotype tend to had highest fasting blood glucose levels and lower hemoglobin levels.

Keywords:
Haptoglobin Phenotypes; Diabetic

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References:

[1]  Barham D, Trind P. 1972 An improved colour for the determination of blood glucose by oxidase system reagent. Analyst.; 97: 142-5.
 
[2]  Bowman, B. 1982. Haptoglobin: evolutionary product of duplication, unequal crossing over, and point mutation. Adv. Hum. Genet. 12, 189-216, 453-454.
 
[3]  Bowman, BH.1993 Haptoglobin. Hebtaic plasma proteins. San Deiego, Academic Press: 159-67.
 
[4]  Carter, K. and Worwood.M. (2007). Haptogolobin: A review of the major allele frequencies worldwide and their association with diseases.IntJ Lab Hematol; 329:977-86. [PubMed: 366922.
 
[5]  Davis BJ. Disc electrophoresis II, method and application to human serum proteins. Ann NY acad Sci. 1964; 121:404-27.
 
[6]  Davis, B. and Orenstein, L. (1968). Disc electrophoresis, acrylamide gel columns. Methods in Immanology and Immanochemistry. Volume II(Ed. By William and Chase); p. 38 Academic Press, New York.
 
[7]  Giblet ER. Genetic markers in human blood. Oxford: Blackwell scientific publication; 1969.
 
[8]  JAMA. 1909 to 1911. The Predictive value of Serum Haptoglobin in Hemolytic disease; 243 (19): 1909-1911.
 
[9]  McCormick and Atassi, 1990. Hepatic Proteins, Mechanism of Function and Regulation. El sevier.
 
[10]  Melamed-Frank M., Lache O., Enva B., Szafrank T., Levy N., Ricklis R, 2001. Structure function analysis of the antioxidant properties of haptoglobin. Blood,98(1):3693-8.
 
[11]  Nakhoul F, Marsh S, Hochberg I, Leibu R, Levy AP 2000.Haptoglobin phenotype and diabetic retinopathy. JAMA.; 284:1244-5.
 
[12]  Polonovski, M. and Jayle, M.F., 1938. Existence dansle plasma humain d, une sunstance activant l, action peroxydasique de l, hemoglobin. C.R. Soc. Biol. 129, 457-461.
 
[13]  Smithies, O., (1955). Genetic control of some serum proteins in normal humans their inheritatnce. Nature; 176. 1265-1266.
 
[14]  Smithies O. 1955; Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem J. 61:629-41
 
[15]  The DCCT Research Group. 1993. The effect of intensive diabetes treatment on the development and progression of long-term complications in insulin-dependent diabetes mellitus: the Diabetes Control and Complications Trail. N Engl. J Med 329:977-86.
 
[16]  Awadallah S, Hamad M. . 2000 The prevalence of type 2 diabetes mellitus is Haptoglobin phenotype-independent. Cytobios; 101(398):145-50.
 
[17]  WHO, Diabetes Mellius. Technical Report Series. 1985; p727.
 
[18]  Hamady G.,Hendy.O., Mahmoud H., El-sebaey A., Ali.S and Khalaf F 2014. Haptoglobin phenotypes as a risk factor for cornory artery disease in type2 diabeties mellitus: An Egptian study. The Egyptian J of Med huma gent. 15: 257-264.
 
[19]  Quaye Ik., Ababio GR., Amoah G.2006. Haptoglobin2-2 phenotype is arik factor for type2 diabaties in Ghana. J Anthrosclero Thrombo 13(2): 90-94.
 
[20]  Abhishikta R., Sarkar P ., bandyopadhyay 2015. Haptoglobin polymorphism and diabatic Nephropathy: Astudy among the Benglee Hindus of West Bengal. Word J Pharm Sci, 3(3):628-631.
 
[21]  Bessa Ss., Hamady SM., Ali EM. 2007. Haptoglobin gene polymorphism in type2 diabatic patients with and without Nephropathy: anEgyptian study. Eur J Intern Med. 18(6):489-95.
 
[22]  Amiri AA.,Hashemi-Soteh MB., Haghshenas MR., Daneshvar F., Rastegar A., Frazmand T.2013. Haptoglobin polymorphism in individuals with type2 diabatic microangiopathy. N Am J Med Sci, 5(9): 529-35.
 
[23]  Adams J., Cox A., Freedman B., Langefeld C., Carr J., Bowden D. 2013. Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type2 diabeties heart study. Cardiovasc Diabetol 12:13.