A Precise Evaluation of Antibacterial Activity of Marine Actinomycetes against Drug Resistant Urinary Tract Bacterial Pathogens

Deepa Mathew P^{1, 2,} and Dr. V. Robin Perinba Smith^{2, 3}

¹Research Scholar, Department of Zoology, Scott Christian College (Autonomous), Nagercoil, Kanyakumari District, Tamilnadu, India, Reg.No.18213082102002

²Affiliated to Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli, 627012, Tamil Nadu, India

³Associate Professor and Head, Department of Zoology, Scott Christian College (Autonomous), Nagercoil, Tamil Nadu, India

Cite this paper:
Deepa Mathew P and Dr. V. Robin Perinba Smith. A Precise Evaluation of Antibacterial Activity of Marine Actinomycetes against Drug Resistant Urinary Tract Bacterial Pathogens. Applied Ecology and Environmental Sciences. 2022; 10(12):723-729. doi: 10.12691/aees-10-12-4

Abstract

Biomolecules produced by marine actinomycetes have peculiar chemical structures that could be utilized to produce novel drugs to combat pathogens with antimicrobial resistance. The objective of the present investigation was to identify antagonistic properties of marine actinomycetes' toward multidrug resistant bacterial pathogens affecting the urinary system. Here, 58 actinomycetes isolates were obtained from the twelve marine sediment samples collected from the coast of Poovar and Shangumugham, Kerala, India. Out of 58 marine actinomycetes isolates, 10 isolates were selected for the study of antagonistic activity against the uropathogens E.coli and Klebsiella pneumoniae collected from a tertiary hospital in Kerala. One actinomycete isolate showed significant antagonistic property against both E.coli and Klebsiella pneumoniae. This isolate was mass cultivated by solid state fermentation and the ethyl acetate extract of its secondary metabolite was partially purified by TLC.

Keywords:
Marine actinomycetes Uropathogens Antagonism Secondary metabolite

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