World Journal of Organic Chemistry. 2015, 3(1), 9-11
DOI: 10.12691/wjoc-3-1-2
Open AccessArticle
Rakesh Choure1, and Neelam Vaidya1
1Department of Chemistry, Dr. Hari Singh Gour University, Sagar
Pub. Date: February 08, 2015
Cite this paper:
Rakesh Choure and Neelam Vaidya. Polarography and Pharmacological Study of Atropine Fe Complex for Its Increased Anesthetic Potency. World Journal of Organic Chemistry. 2015; 3(1):9-11. doi: 10.12691/wjoc-3-1-2
Abstract
Atropine is an anesthetic drug used in anesthesia. Though the drug is being used as anesthetic but it’s potency may be increased by modifying the drug by way of molecular modification, in the present study, the drug has been modified by it’s complex formation with Fe. The drug-metal compound interaction has been studied using differential pulse polarography(DPP). The results of pharmacological study indicated increased potency of complex of atropine and metal as compared to the parent drug that is atropine.Keywords:
atropine DCP DPP anesthetic drug
This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
References:
| [1] | GL Weinberg, T VadeBoncouer, GA Ramaraju, MF Garcia-Amaro, MJ Cwik, Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats, Anesthesiology. (1998) 88: 1071-5. |
| |
| [2] | G Weinberg, R Ripper, DL Feinstein, nduced cardiac toxicity, Regional Anesthesia and Pain Medicine. W Hoffman, Lipid emulsion infusion rescues dogs from bupivacaine-I (2003) 28: 198-202. |
| |
| [3] | J Picard, T Meek, Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob, Anesthesia. (2006) 61: 107-9. |
| |
| [4] | MA Rosenblatt, M Abel, GW Fischer, CJ Itzkovich, JB Eisenkraft, Successful Use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest, Anesthesiology. (2006) 105: 217-8. |
| |
| [5] | RJ Litz, M Popp, S N Stehr, T Koch, Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion, Anaesthesia. (2006) 61:800-1. |
| |
| [6] | HP Rang, MM Dale, JM Ritter, RJ Flower, Ch. 10. Rang and Dale's Pharmacology, Elsevier Churchill Livingstone. (2007) pp. 153. |
| |
| [7] | S Robert, MD Holzman. The Legacy of Atropos. Anesthesiology. (1998) 89 (1): 241-249. |
| |