Synthesis, Characterization and Antifungal Activity of Some Metal Complexes Derived From Quinoxaloylhydrazone

Ahmed Mahal^{1, 2,} , Rajab Abu-El-Halawa^{3, 4,} , Sami A. Zabin⁵, Mohammad Ibrahim³, Mahmoud Al-Refai³ and Tawfeq Kaimari⁶

¹Department of Chemistry, Sultan Qaboos University, Muscat, Sultanate of Oman

²Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy

³Department of Chemistry, Al al-Bayt University, Mafraq, Jordan

⁴Clinical Pharmacy, Al-Baha University, Al Baha, Saudi Arabia

⁵Department of Chemistry, Al-Baha University, Al Baha, Saudi Arabia

⁶Faculty of Pharmacy & Medical Science, Hebron University, Hebron, Palestine

Cite this paper:
Ahmed Mahal, Rajab Abu-El-Halawa, Sami A. Zabin, Mohammad Ibrahim, Mahmoud Al-Refai and Tawfeq Kaimari. Synthesis, Characterization and Antifungal Activity of Some Metal Complexes Derived From Quinoxaloylhydrazone. World Journal of Organic Chemistry. 2015; 3(1):1-8. doi: 10.12691/wjoc-3-1-1

Abstract

New Complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and Tin(II) with 3-methyl-2-(pyridine-2-yl-methylene-hydrazinocarbonyl)quinoxaline-4-oxide (LHP) and 2-(2-hydroxy benzylidene-hydrazinocarbonyl)-3-methylquinoxaline-4-oxide (LHS) were prepared. The new complexes were characterized by elemental analysis, conductivity, magnetic measurements, IR and UV-Vis spectroscopic measurements. The results indicate 1:1 [M:L] chelates with the general formula [M(LHP)Cl₂].nH₂O where: M = Mn(II), n=4, Co(II), n=1/2, Cu(II), n=1, Hg(II), n=1, and 1:2 [M:L] in case of [M(LHS)₂](OAc)₂.nH₂O when M = Zn(II), n= 3, Cd(II), n= 1, Hg(II), n= 1/2. The tin complex structure is suggested to be [Sn(LHP)₂]Cl₂.2H₂O, while copper produces [Cu₂(LHS)₂SO₄].H₂O complexes. Also, the formula for mercuric complex found to be [Hg(LHS)₂Cl₂].2H₂O. The magnetic moment measurements and electronic spectra suggest octahedral geometry for the prepared complexes. The antifungal investigation reveals that the activity was enhanced by chelation. The Cu(II) complexes has the highest inhibition zone against A. niger. But, the antifungal activity was weaker than the standard drug used.

Keywords:
aroyl hydrazone quinoxaline-4-oxide schiff bases metal complexes antifungal activity

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