Synthesis and Evaluation of the Biological Activities of Some Derivatives of 4-Hydroxycoumarin

Yousoufou Bakouan^{1, 2,} , Assétou Sankara³, Benjamin Ouédraogo^{3, 4}, Wend-Kuny Guy Aristide Nitiema², Lassané Tarpaga² and Bintou Sessouma²

¹Centre Universitaire de Ziniaré/ Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso

²Laboratoire de Chimie Moléculaire et de Matériaux, Unité de Formation et de Recherche en Sciences Exactes et Appliquées, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso

³Laboratoire de Chimie Analytique, Environnementale et Bio-Organique (LCAEBiO) Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso

⁴Département de physique et chimie, UFR/ST, Université Ledea Bernard OUEDRAOGO, Burkina Faso;International Research Laboratory IRL 3189 Environment, Health, Societies (CNRST, USTTB, UCAD, UGB, CNRS)

Cite this paper:
Yousoufou Bakouan, Assétou Sankara, Benjamin Ouédraogo, Wend-Kuny Guy Aristide Nitiema, Lassané Tarpaga and Bintou Sessouma. Synthesis and Evaluation of the Biological Activities of Some Derivatives of 4-Hydroxycoumarin. World Journal of Organic Chemistry. 2024; 11(1):1-8. doi: 10.12691/wjoc-11-1-1

Abstract

This article presents the synthesis and antioxidant activities of a series of new C-acylated hydroxycoumarins. The compounds were synthesized and characterized using various spectral methods, including Infrared Spectroscopy, Nuclear Magnetic Resonance, and Mass Spectrometry. The biological activities were determined using the DPPH method by assessing the percentage inhibition of the different synthesized compounds. Four new molecules were successfully synthesized: 3-(4-methylbenzoyl)-4-hydroxycoumarin (a), 3-(4-chlorobenzoyl)-4-hydroxycoumarin (b), 3-(4-nitrobenzoyl)-4-hydroxycoumarin (c), and 3-(3,5-dinitrobenzoyl)-4-hydroxycoumarin (d). The percentage of inhibition of the synthesized compounds varies from 52.13% ± 1.04 to 78.13% ± 0.60. Compound (d) is the most active with an inhibition percentage of 78.13% ± 0.60, followed by compound (c) with an inhibition percentage of 72.68% ± 0.37, then compound (b) with an inhibition percentage of 67.38% ± 0.30, and finally compound (a) with an inhibition percentage of 52.13% ± 1.04. These compounds may exhibit interesting biological activities due to their percentage of inhibition. Therefore, these coumarin-derived compounds could be good antioxidant candidates.

Keywords:
4-hydroxycoumarin C-acylated derivatives Nuclear Magnetic Resonance antioxidant activity

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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