Nanosuspension Technologies for Delivery of Drugs

Sachin S.Pawar^1, , Bajirao R.Dahifale¹, Sandip P.Nagargoje¹ and Rajan S.Shendge¹

¹Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon

Cite this paper:
Sachin S.Pawar, Bajirao R.Dahifale, Sandip P.Nagargoje and Rajan S.Shendge. Nanosuspension Technologies for Delivery of Drugs. Nanoscience and Nanotechnology Research. 2017; 4(2):59-66. doi: 10.12691/nnr-4-2-4

Abstract

Nanotechnology has emerged as an tremendous field in the medicine. Nano refers as particles size range from 1-100nm.Nanosuspensions are the part of nanotechnology. Many drugs have a poor aqueous solubility. The use of drug nanosuspension is an universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. nanosuspension is defined as very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1um, without any matrix material, stabilized by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral, topical, parenteral, ocular and pulmonary routes. The advantages of Nano suspensions are improved drug dispersibility and drug solubilization, increased therapeutic efficacy and reduced toxicity. Therefore, the present review described about achievements of nanosuspensions in drug delivery system in order to improve the solubility, stability and bioavailability of the drugs. This review article describes the preparation methods, characterization and applications of the nanosuspensions.

Keywords:
nanosuspension bioavailability poorly soluble drugs drug delivery high pressure homogenization

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