Acoustical Studies of Molecular Interactions in the Solution of Anti-Malarial Drug

Ritesh Ramdasji Naik^1, , Sheshrao Vitthalrao Bawankar¹ and Vilas Maruti Ghodki¹

¹Jankidevi Bajaj College of Science, Jamnalal Bajaj Marg, Civil Lines Wardha

Cite this paper:
Ritesh Ramdasji Naik, Sheshrao Vitthalrao Bawankar and Vilas Maruti Ghodki. Acoustical Studies of Molecular Interactions in the Solution of Anti-Malarial Drug. Journal of Polymer and Biopolymer Physics Chemistry. 2015; 3(1):1-5. doi: 10.12691/jpbpc-3-1-1

Abstract

In the present study ultrasonic velocity (U), density (ρ) and viscosity (η) have been measured at frequency 1 MHz in the binary mixtures of chloroquine phosphate with water in the concentration range (0.1 to 0.0125 %) at 303 K,308 K,313 K using multi frequency ultrasonic interferometer. The measured value of density, ultrasonic velocity, and viscosity have been used to estimate the acoustical parameters namely adiabatic compressibility (βa), relaxation time (τ), acoustic impedance (z), free length (Lf), free volume (Vf) and internal pressure (Πi), Wada’s constant (W) to investigate the nature and strength of molecular interaction in the binary mixture of chloroquine phosphate hydrochloride with water. The obtained result supports the complex formation, molecular association by intermolecular hydrogen bonding in the binary liquid mixtures.

Keywords:
chloroquine phosphate free volume acoustical parameters ultrasonic velocity

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