A Study of Biochemical and Hematological Markers in Alcoholic Liver Cirrhosis

Neelesh Deshpande¹, Sabitha Kandi², Manohar Muddeshwar¹, Rajkumar Das¹ and K V Ramana^3,

¹Department of Biochemistry ,Government Medical College, Nagpur, India

²Department of Biochemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India

³Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India

Cite this paper:
Neelesh Deshpande, Sabitha Kandi, Manohar Muddeshwar, Rajkumar Das and K V Ramana. A Study of Biochemical and Hematological Markers in Alcoholic Liver Cirrhosis. World Journal of Nutrition and Health. 2014; 2(2):24-27. doi: 10.12691/jnh-2-2-3

Abstract

Progressive fibrosis and cirrhosis, clinically presenting as end-stage liver disease are common outcomes in alcoholic Liver disease (ALD) patients. A variety of laboratory tests are available to assist in the progression and diagnosis of cirrhosis to end stage liver disease. The aim of this study is to identify potential novel biomarkers for progression of cirrhosis to end-stage liver cirrhosis. The biomarkers evaluated in this study included liver function indicators including serum ferritin, prothrombin time, albumin, total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), renal parameters (urea and creatinine) and red blood cell counts, hemoglobin and blood glucose. The study included two groups based on severity of cirrhosis of liver; categorized as compensated and decompensated liver cirrhotic patients based on child Pugh criteria. All decompensated cirrhotic patients in the study group had significantly elevated biomarkers levels (P<0.001) than those with compensated cirrhotic patients and control group who were not suffering from liver cirrhosis. Thus these results suggest that elevated and altered liver and hematological biomarkers are associated with pathogenesis and progression of liver cirrhosis.

Keywords:
alcohol Biochemical marker haematological markers γ-Glutamyltransferase Aminotransferases

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