Platelet Rich Fibrin in Periodontal Practice, Review

Abdullah Saleh Almutairi^1,

¹Department of Periodontics and Oral Medicine, College of Dentistry, Qassim University, KSA

Cite this paper:
Abdullah Saleh Almutairi. Platelet Rich Fibrin in Periodontal Practice, Review. International Journal of Dental Sciences and Research. 2017; 5(5):132-136. doi: 10.12691/ijdsr-5-5-4

Abstract

Autologous platelet concentrates have become a rage in the field of regenerative medicine including numerous specialties like orthopedics, maxillofacial and cosmetic surgery, sports medicine and dentistry. The use of these platelet concentrates ranging from fibrin glues to the currently used platelet-rich fibrin (PRF) has exponentially increased and it has brought about a radical change in the stimulation and acceleration of regenerative tissue processes. The current review highlights the evolution of different platelet concentrates and the use of platelet rich fibrin in periodontal treatment and tissue repair.

Keywords:
platelet rich concentrates platelet rich fibrin periodontics regeneration tissue repair

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

References:

[1]	Mosesson MW, Siebenlist KR, Meh DA. The structure and biological features of fibrinogen and fibrin. Ann N Y Acad Sci. 2001; 936: 11-30.
[2]	Clark RA. Fibrin and wound healing. Ann N Y Acad Sci. 2001; 936: 355-67.
[3]	Collen A, Koolwijk P, Kroon M, van Hinsbergh VW. Influence of fibrin structure on the formation and maintenance of capillary-like tubules by human microvascular endothelial cells. Angiogenesis. 1998; 2(2): 153-65.
[4]	Matras H. Fibrin sealant in maxillofacial surgery. Development and indications. A review of the past 12 years. Facial PlastSurg FPS. 1985; 2(4): 297-313.
[5]	Chabbra S, Chabbra N, Vaid P. Platelet Concentrates: A New Alternative to Bone Regeneration. 2013 Jan 8; 2(2): 118-21.
[6]	Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1998 Jun; 85(6): 638-46.
[7]	Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009 Mar; 27(3): 158-67.
[8]	Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2006 Mar; 101(3): e37-44.
[9]	Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author’s Perspective. J Cutan Aesthetic Surg. 2014 Dec; 7(4): 189-97.
[10]	van Hinsbergh VW, Collen A, Koolwijk P. Role of fibrin matrix in angiogenesis. Ann N Y Acad Sci. 2001; 936: 426-37.
[11]	Li Q, Pan S, Dangaria SJ, Gopinathan G, Kolokythas A, Chu S, et al. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. BioMed Res Int. 2013; 2013: 638043.
[12]	Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol. 2011 Dec; 82(12): 1705-12.
[13]	Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol. 2011 Oct; 82(10): 1396-403.
[14]	Anilkumar K, Geetha A, Umasudhakar null, Ramakrishnan T, Vijayalakshmi R, Pameela E. Platelet-rich-fibrin: A novel root coverage approach. J Indian SocPeriodontol. 2009 Jan; 13(1): 50-4.
[15]	Ozdemir H, Ezirganli S, Isa Kara M, Mihmanli A, Baris E. Effects of platelet rich fibrin alone used with rigid titanium barrier. Arch Oral Biol. 2013 May; 58(5): 537-44.
[16]	Shah M, Patel J, Dave D, Shah S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J Indian SocPeriodontol. 2015 Feb; 19(1): 56-60.
[17]	Gassling V, Douglas T, Warnke PH, Açil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010 May; 21(5): 543-9.
[18]	Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte M-P, Charrier J-B. In vitro effects of Choukroun’s PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral RadiolEndodontology. 2009 Sep; 108(3): 341-52.
[19]	Neiva RF, Gil LF, Tovar N, Janal MN, Marao HF, Bonfante EA, et al. The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs. BioMed Res Int. 2016; 2016: 9507342.
[20]	Şimşek S, Özeç İ, Kürkçü M, Benlidayı E. Histomorphometric Evaluation of Bone Formation in Peri-Implant Defects Treated With Different Regeneration Techniques: An Experimental Study in a Rabbit Model. J Oral MaxillofacSurg Off J Am Assoc Oral Maxillofac Surg. 2016 Sep; 74(9): 1757-64.
[21]	Choukroun J, Diss A, Simonpieri A, Girard M-O, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2006 Mar; 101(3): 299-303.
[22]	Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant Dent. 2009 Apr; 18(2): 102-11.
[23]	Thakkar DJ, Deshpande NC, Dave DH, Narayankar SD. A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study. Contemp Clin Dent. 2016 Sep; 7(3): 371-6.
[24]	He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2009 Nov; 108(5): 707-13.
[25]	Chang I-C, Tsai C-H, Chang Y-C. Platelet-rich fibrin modulates the expression of extracellular signal-regulated protein kinase and osteoprotegerin in human osteoblasts. J Biomed Mater Res A. 2010 Oct; 95(1): 327-32.
[26]	Tsai C-H, Shen S, Zhao J, Chang Y-C. Platelet-rich fibrin modulates cell proliferation of human periodontally related cells in vitro. J Dent Sci. 6.
[27]	Lee S. H., Kim S. W., Lee J. Il. & Yoon H. J. The effect of platelet-rich fibrin on bone regeneration and angiogenesis in rabbit cranial defects. Tissue Eng. Regen. Med. 12, 362-370 (2015).
[28]	Kökdere NN, Baykul T, Findik Y. The use of platelet-rich fibrin (PRF) and PRF-mixed particulated autogenous bone graft in the treatment of bone defects: An experimental and histomorphometrical study. Dental Research Journal. 2015; 12(5): 418-424.
[29]	Eren G, Atilla G. Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig. 2014 Nov; 18(8): 1941-8.
[30]	Öncü E. The Use of Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft in Treatment of Multiple Gingival Recessions: A Randomized Clinical Trial. Int J Periodontics Restorative Dent. 2017 Mar/Apr; 37(2): 265-271.
[31]	Amine K, El Amrani Y, Chemlali S, Kissa J. Alternatives to connective tissue graft in the treatment of localized gingival recessions: A systematic review. J Stomatol Oral Maxillofac Surg. 2017 Sep 9. pii: S2468-7855(17)30154-4.
[32]	He Y, Chen J, Huang Y, Pan Q, Nie M. Local Application of Platelet-Rich Fibrin During Lower Third Molar Extraction Improves Treatment Outcomes. J Oral Maxillofac Surg. 2017 Jun 8. pii: S0278-2391(17)30611-0.
[33]	Thorat M, Baghele ON, S RP. Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial. Int J Periodontics Restorative Dent. 2017 Nov/Dec; 37(6): e302-e309.
[34]	Ocak H, Kutuk N, Demetoglu U, Balcıoglu E, Ozdamar S, Alkan A. Comparison of Bovine Bone-Autogenic Bone Mixture Versus Platelet-Rich Fibrin for Maxillary Sinus Grafting: Histologic and Histomorphologic Study. J Oral Implantol. 2017 Jun; 43(3): 194-201.
[35]	Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, Fujioka-Kobayashi M, Bishara M, Zhang Y, Wang HL, Chandad F, Nacopoulos C, Simonpieri A, Aalam AA, Felice P, Sammartino G, Ghanaati S, Hernandez MA, Choukroun J. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig. 2017 Jul; 21(6): 1913-1927.
[36]	Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Annals of Maxillofacial Surgery. 2011; 1(1): 53-57.