Effect of Vascular Endothelial Growth Factor Expression in the Destruction and Healing Stages of Chronic Periodontal Disease: A Case Report

Alaa Abdelhamid^1,

¹Periodontology and Oral Medicine Department, Qassim College of Dentistry, Qassim University, Saudi Arabia

Cite this paper:
Alaa Abdelhamid. Effect of Vascular Endothelial Growth Factor Expression in the Destruction and Healing Stages of Chronic Periodontal Disease: A Case Report. International Journal of Dental Sciences and Research. 2017; 5(2):35-38. doi: 10.12691/ijdsr-5-2-5

Abstract

Vascular endothelial growth factor (VEGF) is a homodynamic protein produced by different cells as endothelial cells, macrophages, T-cells. In epithelial and endothelial cells, VEGF has been reported more in periodontitis than in sites with gingivitis, suggesting that it could be a crucial factor for the initiation of gingivitis and its transition to periodontitis. Objective: To determine the effect of non-surgical periodontal treatment on VEGF expression on gingival tissues with chronic periodontitis. Methods: Gingival samples (2-3 mm) were collected immediately before and 4 weeks after non-surgical periodontal therapy from a 48-year-old male with chronic periodontitis. The samples were treated with immunohistochemically. Results: A decrease in VEGF expression was observed in gingival tissues following non-surgical periodontal treatment. Conclusion: VEGF is continually produced and expressed in healthy and diseased gingival tissues; non-surgical periodontal therapy with antibiotics combination significantly affects the expression pattern of VEGF as a biomarker.

Keywords:
chronic periodontitis non-surgical periodontal therapy vascular endothelial growth factor

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