International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: Editor-in-chief: Marcos Roberto Tovani Palone
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International Journal of Dental Sciences and Research. 2014, 2(3), 50-54
DOI: 10.12691/ijdsr-2-3-1
Open AccessReview Article

Fibroblast Heterogeneity in Periodontium – a Review

Dr. A. Archana1, Dr. Venkata Srikanth2, Dr. Sasireka2, Dr. Bobby Kurien2, and Dr. Ebenezer2

1Department of Periodontics, Madha Dental College, Chennai, India

2Department of Periodontics, Adhiparasakthi Dental College, Chennai, India

Pub. Date: May 11, 2014

Cite this paper:
Dr. A. Archana, Dr. Venkata Srikanth, Dr. Sasireka, Dr. Bobby Kurien and Dr. Ebenezer. Fibroblast Heterogeneity in Periodontium – a Review. International Journal of Dental Sciences and Research. 2014; 2(3):50-54. doi: 10.12691/ijdsr-2-3-1


Fibroblast heterogeneity applies to both phenotypic and functional properties exhibited by a fibroblast population within or across tissues (Mc Culloch et al) There is significant evidence that fibroblasts are heterogeneous with respect to functional properties, and that certain subpopulations of these cells may be clonally selected and expanded in diseased tissues. There are wide variations of gene expression and strikingly different responses to extracellular signals among different fibroblast populations. This has prompted a large number of in vitro studies which suggest that fibroblasts are not homogeneous but instead comprise multiple subpopulations with extensive site-to-site and intra-site variations.

periodontal ligament fibroblasts collagen Alkaline phosphatase

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