LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIA

Neha Seshadri¹ and Wilma Delphine Silvia CR^2,

¹Wayne State University, Detroit, Michigan, USA/Skyline High School Ann Arbor Michigan, USA.

²Department of Biochemistry, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Bengaluru- 562110, India.

Cite this paper:
Neha Seshadri and Wilma Delphine Silvia CR. LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIA. International Journal of Clinical and Diagnostic Research. 2017; 5(6):175-180. doi: 10.12691/ijcdr-5-6-2

Abstract

Heparin-induced thrombocytopenia (HIT) is a common clinical condition. There are two types of Heparin-induced thrombocytopenia: type I and type II. Type I is a self-limiting condition, where platelet counts will return to normal within a few days. Type II is a very critical clinical condition associated with thrombotic events in arterial and venous systems. Though its clinical status raises a high degree of suspicion, definitive diagnosis includes laboratory testing for platelet activation (SRA) and antigen assays (PF4 ELISA). The purpose of this review is to provide an overview of the biochemical markers for Heparin-induced thrombocytopenia, especially for type II.

Keywords:
Heparin-induced thrombocytopenia Platelet Factor 4 Serotonin Release Assay Heparin-induced-platelet activation test

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