STUDY OF OXIDATIVE PARAMETERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Sujatha Pasula^1, and S Praveena¹

¹Department of Biochemistry, Kamineni Academy of Medical Sciences and Research Center, L.B.Nagar, Hyderabad. Telangana. India.

Cite this paper:
Sujatha Pasula and S Praveena. STUDY OF OXIDATIVE PARAMETERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). International Journal of Clinical and Diagnostic Research. 2017; 5(3):100-109. doi: 10.12691/ijcdr-5-3-5

Abstract

Background: Chronic obstructive pulmonary disease (COPD) proven fact as strong association with oxidative stress. Methods: Total number of 200 patients was studied, comprising of 100 healthy controls and 100 COPD cases. Among 100 COPD cases diagnosed, 50 were of chronic bronchitis cases and 50 were emphysema cases. Patient’s serum was estimated for vitamin- C, reduced glutathione, superoxide dismutase activity and MDA. Results: In comparison to controls, levels of reduced glutathione, Vit-C and SOD activity are significantly decreased in COPD cases. In emphysema patients also there was significant decrease in erythrocyte reduced glutathione, vitamin C and SOD activity. In comparison to chronic bronchitis cases there was significant increase in MDA in emphysema patients when compared to chronic bronchitis patients. Conclusion: Imbalance in antioxidants status of erythrocyte reduced glutathione, SOD activity and vit- C in COPD patients is mainly a consequence of increased oxidative stress, which can be corrected by dietary supplements.

Keywords:
Oxidative stress Vitamin C Superoxide dismutase; Malondialdehyde

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