ASSESSMENT OF THIOBARBITURIC ACID REACTIVE SUBSTANCE AND VITAMIN C IN PATHOGENESIS OF DIABETIC NEUROPATHY

Shilpashree Yeliyur Dhananjaya^1, and Tejaswi Heremarali Lokanathan²

¹Department of Biochemistry, Adichunchanagiri Institute of Medical Sciences, BG Nagara, Karnataka, India -571448

²Department of Anatomy, Adichunchanagiri Institute of Medical Sciences, BG Nagara, Karnataka, India -571448

Cite this paper:
Shilpashree Yeliyur Dhananjaya and Tejaswi Heremarali Lokanathan. ASSESSMENT OF THIOBARBITURIC ACID REACTIVE SUBSTANCE AND VITAMIN C IN PATHOGENESIS OF DIABETIC NEUROPATHY. International Journal of Clinical and Diagnostic Research. 2016; 4(6):124-129. doi: 10.12691/ijcdr-4-6-2

Abstract

One of the most common complications of diabetes is diabetic neuropathy. The factor that is associated with the development of diabetic neuropathy is increased oxidative stress which in turn releases free radical and decreases antioxidant defense. This cross sectional study was carried out in the JSS Medical College, Mysore, Department of Biochemistry. Thirty patients with diabetic neuropathy and 30 unrelated age and sex matched healthy controls were included in the study. EDTA whole blood was used to estimate Glycated haemoglobin. Serum sample was used to estimate serum thiobarbituric acid reactive substance (TBARS) and Vitamin C levels. Mean serum TBARS levels were significantly greater in diabetic neuropathy. There was a statistically significant negative correlation between serum TBARS and Vitamin C in cases (r=-0.176). Highly significant negative correlation was found between Vitamin C and HbA1c in cases (r=-0.168). In this study we found that there is an inverse relationship between TBARS and vitamin C in diabetic neuropathy and it may be a result of poor Glycemic control.

Keywords:
oxidative stress ascorbic acid hyperglycemia HbA1C

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