INTER-RELATIONSHIP OF GLYCEMIC CONTROL AND THYROID STATUS IN TYPE – 2 DIABETES MELLITUS

Suresh DR¹, Wilma Delphine Silvia CR^2, and Krishna Murthy U³

¹Associate Professor, Dept of Biochemistry, Akash Institute of Medical Sciences & Research Centre, Bangalore.

²Professor & HOD, Dept of Biochemistry, Akash Institute of Medical Sciences & Research Centre, Bangalore.

³Associate Professor, Department of Biochemistry, MS Ramaiah Medical College, Bangalore.

Cite this paper:
Suresh DR, Wilma Delphine Silvia CR and Krishna Murthy U. INTER-RELATIONSHIP OF GLYCEMIC CONTROL AND THYROID STATUS IN TYPE – 2 DIABETES MELLITUS. International Journal of Clinical and Diagnostic Research. 2014; 2(4):71-76. doi: 10.12691/ijcdr-2-4-5

Abstract

Introduction: The inter-relationship between diabetes mellitus & thyroid disorders involves biochemical, genetic, hormonal and pathophysiological mechanisms under the influence of endocrine and non-endocrine organs other than the pancreas. Several studies document the prevalence of thyroid dysfunction among type-2 diabetes mellitus patients to be varying from 2.2 to 17 %. However, fewer studies have estimated much higher prevalence of thyroid dysfunction (31 % and 46.5%) in Type – 2 diabetes mellitus. Materials and Methods: This cross-sectional pilot study involved 81 confirmed cases ofType – 2 diabetes mellitus (on treatment) aged between 18-70 years of either sex(male-24, female-57). Blood samples were analyzed for FBS, PPBS, RBS and thyroid profile (Total T3, total T4 & TSH) tests. The results obtained were expressed asMean ± SD. Results: The prevalence of thyroid dysfunction was 37% [Hypothyroidism - 30% & Hyperthyroidism - 7%].Based on glycemia control & thyroid status, following subcategories of cases were observed: Euglycemic Euthyroid (42%) > Hyperglycemic euthyroid (21%) > Euglycemic hypothyroidism / Euglycemic subclinical hypothyroidism (11%) > Hyperglycemic subclinical hypothyroidism (5%) > Euglycemic subclinical hyperthyroidism (4%) > Hyperglycemic hypo/hyperthyroidism (2%). Conclusion: Determining thyroid status may be useful for better management of type – 2 DM and its prognosis.

Keywords:
thyroid;diabetes mellitus; TSH; insulin; hyperglycemia.

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