International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2017, 5(3), 97-100
DOI: 10.12691/ijcd-5-3-1
Open AccessArticle

Anti-tTg-IgA is neither a Solved Problem nor a “closed case” in Celiac Disease Diagnosis

Aaron Lerner1, 2, , Sandra Neidhöfer2 and Torsten Matthias2

1B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

2AESKU.KIPP Institute, Wendelsheim

Pub. Date: August 08, 2017

Cite this paper:
Aaron Lerner, Sandra Neidhöfer and Torsten Matthias. Anti-tTg-IgA is neither a Solved Problem nor a “closed case” in Celiac Disease Diagnosis. International Journal of Celiac Disease. 2017; 5(3):97-100. doi: 10.12691/ijcd-5-3-1


Anti-tissue transglutaminase (tTg) IgA are considered the most frequently used serological marker for celiac disease diagnosis. Despite its recommended leading position by the 2012 ESPGHAN diagnostic criteria, it exposes multiple false positive and negative titers. In view of the critical opinions expressed lately in the literature against the application of those criteria, the bias in the central place occupied by tTg-IgA in the new ESPGHAN CD Diagnostic Guidelines and the emergence of newer serological marker for celiac disease, it is hoped that the revised guidelines will open up the limited, problematic and single Tg2-IgA antibody for other or additional single or combined serological diagnostic markers.

celiac disease antibody diagnosis tissue transglutaminase neo-epitope microbial transglutaminase

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