Extra Intestinal Manifestations of CD: Common Pathways in the Gut- remote Organs’ Axes

Aaron Lerner^{1, 2,} and Torsten Matthias²

¹B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

²AESKU.KIPP Institute, Wendelsheim, Germany

Cite this paper:
Aaron Lerner and Torsten Matthias. Extra Intestinal Manifestations of CD: Common Pathways in the Gut- remote Organs’ Axes. International Journal of Celiac Disease. 2017; 5(1):24-27. doi: 10.12691/ijcd-5-1-5

Abstract

Genetic and environmental risk factors for celiac disease are well established, however, the precipitating events leading to development of celiac disease and associated conditions remain enigmatic. Being a multi-faced, multi-organ disease and the multiple extra intestinal phenotypes of celiac disease, further more add to its complexity. The present editorial summarizes the potential mechanisms connecting gut eco system events to remote organ manifestations and dysfunctions in celiac disease. It is suggested that nutrients, the microbiome/dysbiome interplay, the local post translational modification of naive proteins, the leaky gut and the leaked immunogenic or toxic molecules or complexes and the circulating pro-inflammatory immune cells and cytokines are at the basis of the gut-remote organ pathologies, in CD.

Keywords:
celiac diseases potential mechanisms gut eco system

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