The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency

Ludmila Tankova¹, Vanya Gerova¹, Plamen Getsov², Nikolay Penkov³, Gergana Taneva¹, Ivan Terziev⁴ and Radislav Nakov^1,

¹Clinic of Gastroenterology, Clinical Center of Gastroenterology, University Hospital “Queen Joanna”, Sofia, Bulgaria

²Department of Radiology, University Hospital “Queen Joanna”, Sofia, Bulgaria

³Clinic of Abdominal Surgery, Clinical Center of Gastroenterology, University Hospital “Queen Joanna”, Sofia, Bulgaria

⁴Department of Pathology, University Hospital “Queen Joanna”, Sofia, Bulgaria

Cite this paper:
Ludmila Tankova, Vanya Gerova, Plamen Getsov, Nikolay Penkov, Gergana Taneva, Ivan Terziev and Radislav Nakov. The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency. International Journal of Celiac Disease. 2016; 4(1):30-33. doi: 10.12691/ijcd-4-1-8

Abstract

Concomitant occurrence of celiac disease (CeD) and Crohn’s disease (CD) is rare and has been reported in several case reports and series. We report a case of a 63-year-old man with proximal CD, CeD and selective immunoglobulin (Ig) A deficiency (SIgAD). The patient was admitted in our Clinic for evaluation of epigastric pain, nausea, vomiting and weight loss (up to 7 kg) appeared in the last 3 months. The imaging findings from abdominal ultrasound and CT enterography raised suspicion of a lymphoproliferative disease of the jejunum. To exclude the development of lymphoma based on long standing untreated atypical CeD, upper endoscopy with biopsies and serological tests were conducted, showing and subtotal villous atrophy and elevated levels of IgG tissue transglutaminase tTG. Histopathology documented CD (A3,L4,B2 according to Montreal’s classification).

Keywords:
silent celiac disease selective Ig A deficiency Crohn’s Disease

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