Is HLA Typing a Diagnostic Tool in Celiac Disease?

Andreea L. Rachisan^1, , Alexandru Pirvan¹, Nicolae Miu¹, Dan Gheban², Adrian Hrusca³, Gabriel Samasca⁴ and Iulia Lupan⁵

¹Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

²Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

³Department of Biophysics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

⁴Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

⁵Department of Molecular Biology, Babes-Bolyai University, Cluj-Napoca, Romania

Cite this paper:
Andreea L. Rachisan, Alexandru Pirvan, Nicolae Miu, Dan Gheban, Adrian Hrusca, Gabriel Samasca and Iulia Lupan. Is HLA Typing a Diagnostic Tool in Celiac Disease?. International Journal of Celiac Disease. 2016; 4(1):9-10. doi: 10.12691/ijcd-4-1-10

Abstract

The “four out of five rule” has not been officially endorsed by official guidelines. However, HLA-associated genes that predispose to CD are found in as much as 30–40% of healthy people. Thus, their presence seems too indecisive for the occurrence of CD.

Keywords:
celiac disease HLA children

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