Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors

Pavel Procházka^{1, 2,}

¹Department of the Molecular Biology of Cancer, Institute of Experimental Medicine AS CR, Prague, Czech Republic

²Institute of Biology and Medical Genetics, First Faculty of Medicine Charles University, Prague, Czech Republic

Cite this paper:
Pavel Procházka. Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors. International Journal of Celiac Disease. 2014; 2(3):93-96. doi: 10.12691/ijcd-2-3-6

Abstract

Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with CTNNB1, VHL, CDKN2A, KRAS, TP53, RNF43, SMAD4, GNAS, PRSS1, ATM, BRCA1, BRCA2, PALB2, STK11 and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases.

Keywords:
celiac disease pancreatic tumors HLA-DQ2 gene locus DQ8 gene locus KRAS BRCA1/2

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References:

[1]	Lazenby AJ, Yardley JH, Giardiello FM, Jessurun J, Bayless TM. “Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis.” Hum Pathol. 20(1). 18-28. 1989.
[2]	Abdo A A, Beck P. “Diagnosis and management of microscopic colitis.” Can. Farm.Physician. 2003.49.1473-78.
[3]	Liszka Ł, Woszczyk D, Pajak J. “Histopathological diagnosis of microscopic colitis.” J Gastroenterol Hepatol. 21(5). 792-7. 2006.
[4]	Pardil DS, Ramnath VR, Loftus EV, Tremaine WJ, Sandborn WJ. “Lymphocytic colitis: clinical features, treatment and outcomes.” Am. J. Gastrenterol. 97(11). 2829-33. 2002.
[5]	Geramizadeh B, Taghavi A, Banan B. Clinical, endoscopic and pathologic spectrum of non-steroidal anti-inflammatory drug-induced colitis. Indian J. Gastroenterol. 28(4). 150-3. 2009.
[6]	Beaugerie L, Pardi DS. “Review article: drug-induced microscopic colitis - proposal for a scoring system and review of the literature.”Aliment Pharmacol Ther. 22(4). 277-84. 2005.
[7]	Helal TE, Ahmed NS, El-Fotoh OA. “Lymphocytic colitis: a clue to bacterial etiology.” World J. Gastroenterol. 11(46). 7266-71. 2005.
[8]	Kitchen PA, Levi AJ, Domizio P, Talbot IC, Forbes A, Price A. “Microscopic colitis: the tip of the iceberg? “Eur J Gastroenterol Hepatol 14.1199-204. 2002.
[9]	El-Matary W, Girgis S, Huynh H, Turner J, Diederichs B. “Microscopic Colitis in Children”. Dig.Dis.Sci 55.1996-2001.2010.
[10]	Price A.B. “The Sydney System: Histological division.” J Gastroenterol Hepatol 6. 209-22. 1991.
[11]	Oberhuber G, Granditsch G, Vogelsang H. “The histopathology of celiac disease: time for a standardized report scheme for pathologists.” Eur J Gastroenterol Hepatol 11. 1185-94. 1999.
[12]	Ozturk Y, Soylu O, OzerE. “Lymphocytis colitis in a child with non-responsive celiac disease.” Acta Gastroenterol Belg 71(4). 393-510. 2008.
[13]	Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S. “Diagnosis and management of microscopic colitis.” World J Gastroenterol 14(48). 7280-88. 2008.
[14]	Olesen M, Eriksson S, Bohr J, Jarnerot JG, Tysk C. “Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients.” Gut. 53(4). 536-41. 2004.
[15]	Olesen M, Eriksson S, Bohr J, Jarnerot G, Tysk C.”Microscopic colitis: A common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998.” Gut. 53(3). 346-50. 2004.
[16]	A. Sonnenberg, R. M. Genta “Lymphocytic and Collagenous colitis: Epidemiologic Differences and similarities.” Dig.Dis. Sci 58. 2970-2975. 2013.
[17]	Fassano A, Troncone R, Branski D (eds) Frontiers in Celiac Disease. Pediatr Adolesc Med. Karger, Basel, 2008.12.18-22.
[18]	Jaskiewicz K, Rzepko R, Adrych K, Smoczynski M. “Microscopic colitis in routine colonoscopies.” Dig-Dis-Sci. 51(2). 241-4. 2006.
[19]	Geboes K. “Lymphocytic, collagenous and other microscopic colitides: pathology and the relationship with idiopathic inflammatory bowel diseases.” Gastroenterol. Clin.Biol. 32(8-9). 689-94. 2008.
[20]	Gillett HR, Freeman HJ “Prevalence of celiac disease in collagenous and lymphocytic colitis.” Can. J. Gastroenterol. 14(11). 919-21. 2000.
[21]	Nyhlin N, Bohr J, Eriksson S, Tysk C. “Systematic review: microscopic colitis.” Aliment. Pharmacol. Ther. 23(11). 1525-34. 2006.
[22]	Leeds JS, Horoldt BS, Sidhu R, Hopper AD, Robinson K, Toulson B et al.”Is there association between celiac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls.” Scan J Gastroenterol 42. 1214-1220. 2007.
[23]	Fine KD, Lee EL, Meyer L “Colonic histopatology in untreted celiac spurenor refractory spure: is it lymphocytic colitis or colonic lymphocytosis?” Hum Pathol 29. 1433-40. 1998.
[24]	Najarian RM, Hait EJ, Leichtner AM, Glickman AJ, Antonioli DA, Goldsmith JD. “Clinical significance of colonic intraepithelil lymphocytosis in a pediatric population.” Mod.Pathol. 22(1). 13-20. 2009.
[25]	Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, Mulder CJ.”Sensitivity of antyendomysium and antygliandin antybodies in untreated celiac disease: disappointing in clinical practice.” Am. J. Gastroenterol. 94.888-894. 1999.
[26]	Carmack SW, Lash RH, Gulizia JM, Genta RM: “Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist.” Adv. Anat.Pathol. 16(5). 290-306. 2009.
[27]	Wu TT, Hamilton: SR. “Lymphocytic gastritis: association with etiology and topology.” Am. J. Surg. Pathol.Feb. 23(2). 153-58. 1999.
[28]	Loftus EV. “Microscopic colitis: epidemiology and treatment.” Am J Gastroenterol 98 (12supl.). 31-36. 2003.