International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2020, 8(3), 110-116
DOI: 10.12691/ijcd-8-3-8
Open AccessReview Article

A Systematic Review on Use of Liver Function Tests to Assess Association between Liver Injury and COVID 19 Disease

Richard Chinaza IKEAGWULONU1, Nkereuwem Sunday ETUKUDOH2, Mark Uchejeso OBETA3, , Henry Chukwuemeka URO-CHUKWU4 and ImohEtim IBANGA5

1Department of Chemical Pathology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki-Nigeria

2Department of Haematology, Federal School of Medical Laboratory Science, Jos, Nigeria

3Department of Medical Laboratory Management, Federal School of Medical Laboratory Science, Jos, Nigeria

4Department of Community Medicine, College of Health Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria

5Department of Chemical Pathology, Federal School of Medical Laboratory Science, Jos, Nigeria

Pub. Date: August 02, 2020

Cite this paper:
Richard Chinaza IKEAGWULONU, Nkereuwem Sunday ETUKUDOH, Mark Uchejeso OBETA, Henry Chukwuemeka URO-CHUKWU and ImohEtim IBANGA. A Systematic Review on Use of Liver Function Tests to Assess Association between Liver Injury and COVID 19 Disease. International Journal of Celiac Disease. 2020; 8(3):110-116. doi: 10.12691/ijcd-8-3-8


BACKGROUND: As at 27th of June 2020, the COVID 19 pandemic had affected 9,653,048 people across the world including 491,128 deaths. We reviewed different studies on liver function tests in COVID 19 patients to better understand how the liver injury is associated with COVID 19 disease. METHODS: A review of the literature was carried out between18th May and 10thJune 2020 on the studies that investigated liver function tests in COVID 19 patients as a marker of liver injury in the patients. The databases used were Pubmed/Medline, Google Scholar and JSTOR and the search protocol involves a combination of words like laboratory diagnosis, liver function tests and COVID 19, SARS-COV-2 and coronavirus. RESULT: Twelve relevant articles were identified out of a total of 212 articles that were initially identified after duplicates were removed. The twelve articles reviewed comprise of 1,926 COVID 19 infected patients representing 1,003(52.1%) males and 923(47.9%) females. Comparing mild to severe cases of COVID 19, the most prevalent laboratory findings were increased AST (100%), ALT (91.7%) and total bilirubin (71.4%), as well as 100%, decreased serum level of albumin. CONCLUSION: Liver injury is associated with COVID 19 as evident with observed changes in serum levels of liver enzymes, bilirubin and albumin in these individuals.

SARS-CoV-2 COVID-19 medical laboratory diagnosis liver function tests

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