International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: https://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2020, 8(1), 35-38
DOI: 10.12691/ijcd-8-1-7
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Are My Patients with Celiac Disease at Higher Risk of COVID-19 Virus?

Lerner Aaron1,

1Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Pub. Date: April 27, 2020

Cite this paper:
Lerner Aaron. Are My Patients with Celiac Disease at Higher Risk of COVID-19 Virus?. International Journal of Celiac Disease. 2020; 8(1):35-38. doi: 10.12691/ijcd-8-1-7

Abstract

COVID-19, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), is now a worldwide spreading pandemic. Most of the attention is directed to the upper and lower respiratory airways, however, it appears that the gastrointestinal tract is also inoculated and infected. In this regards, celiac disease patients are a potential high-risk group for the corona virus infection and the endoscopist communities should be aware of their professional risks.

Keywords:
celiac disease covid-19 SARS-CoV-2 corona virus high risk immune deficiency gastrointestinal endoscopy

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Wikipediade.wikipedia.org ›wiki› COVID-19 pandemic. last edited on 28 March 2020.
 
[2]  Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020.
 
[3]  Papatsiros VG, Stylianaki I, Papakonstantinou G, Papaioannou N, Christodoulopoulos G. Case Report of Transmissible Gastroenteritis Coronavirus Infection Associated with Small Intestine and Brain Lesions in Piglets. Viral Immunol. 2019; 32: 63-67.
 
[4]  Tasker S. Diagnosis of feline infectious peritonitis: Update on evidence supporting available tests. J Feline Med Surg. 2018; 20: 228-243.
 
[5]  Pusterla N, Vin R, Leutenegger CM, Mittel LD, Divers TJ. Enteric coronavirus infection in adult horses. Vet J. 2018; 231: 13-18.
 
[6]  Zhou P, Fan H, Lan T, Yang XL, Shi WF, Zhang W, et al. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature. 2018; 556(7700): 255-258.
 
[7]  Mandelik R, Sarvas M, Jackova A, Salamunova S, Novotny J, Vilcek S. First outbreak with chimeric swine enteric coronavirus (SeCoV) on pig farms in Slovakia - lessons to learn. Acta Vet Hung. 2018; 66: 488-492.
 
[8]  Yao XH, Li TY, He ZC, Ping YF, Liu HW, Yu SC, et al. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020 Mar 15; 49(0): E009.
 
[9]  Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, et al. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Sci Adv. 2017; 3: eaao4966.
 
[10]  Bittar C, Machado RRG, Comelis MT, Bueno LM, Beguelini MR, Morielle-Versute E, et al. Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil. Microb Ecol. 2020; 79: 203-212.
 
[11]  Mackenzie JS, Smith DW. COVID-19: a novel zoonotic disease caused by a coronavirus from China: what we know and what we don’t. Microbiol Aust. 2020 Mar 17: MA20013.
 
[12]  Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020; 9: 386-389.
 
[13]  Levy J, Bernstein L, Silber N. Celiac disease: an immune dysregulation syndrome. Curr Probl Pediatr Adolesc Health Care. 2014; 44: 324-7.
 
[14]  Malamut G, Cording S, Cerf-Bensussan N. Recent advances in celiac disease and refractory celiac disease. F1000Res. 2019 Jun 26; 8. pii: F1000 Faculty Rev-969.
 
[15]  Frossi B, De Carli M, Calabrò A.Coeliac Disease and Mast Cells. Int J Mol Sci. 2019;20. pii: E3400.
 
[16]  Ghasiyari H, Rostami-Nejad M, Amani D, Rostami K, Pourhoseingholi MA, Asadzadeh-Aghdaei H, et al. Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease. J Immunol Res. 2; 2018: 7587095.
 
[17]  Lahdenperä A, Ludvigsson J, Fälth-Magnusson K, Högberg L, Vaarala O. The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease. Scand J Gastroenterol. 2011; 46: 538-49.
 
[18]  Goel G, Daveson AJM, Hooi CE, Tye-Din JA, Wang S, Szymczak E, et al. Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease. Clin Exp Immunol. 2020; 199: 68-78.
 
[19]  Hmida NB, Ben Ahmed M, Moussa A, Rejeb MB, Said Y, Kourda N, et al. Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease? Am J Gastroenterol. 2012; 107: 604-11.
 
[20]  Sharma N, Bhatia S, Chunduri V, Kaur S, Sharma S, Kapoor P, et al. Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them. Front Nutr. 2020; 7: 6.
 
[21]  Chow MA, Lebwohl B, Reilly NR, Green PH. Immunoglobulin A deficiency in celiac disease. J Clin Gastroenterol. 2012; 46: 850-4.
 
[22]  Gommerman JL, Rojas OL, Fritz JH. Re-thinking the functions of IgA+ plasma cells. Gut Microbes. 2014; 5: 652-662.
 
[23]  Guo L, Ren L, Yang S, Xiao M, Chang, Yang F, et al. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clin Infect Dis. 2020 Mar 21. pii: ciaa310.
 
[24]  Giorgio F, Principi M, Losurdo G, Piscitelli D, Iannone A, Barone M, et al. Seronegative Celiac Disease and Immunoglobulin Deficiency: Where to Look in the Submerged Iceberg? Nutrients. 2015; 7: 7486-504.
 
[25]  Uzzan M, Ko HM, Mehandru S, Cunningham-Rundles C. Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD). Curr Gastroenterol Rep. 2016; 18: 17.
 
[26]  Woodward J. Improving outcomes of refractory celiac disease - current and emerging treatment. Clin Exp Gastroenterol. 2016; 9: 225-36.
 
[27]  Yaqoob Z, Al-Kindi SG, Zein J. Association Between Celiac Disease and Asthma. Dig Dis Sci. 2016; 61: 3636-3637.
 
[28]  Pichardo C, Muinos W, Brathwaite C, Hernandez E. Pulmonary Hemosiderosis Associated With Celiac Disease: Lane Hamilton Syndrome. J Pediatr Gastroenterol Nutr. 2017; 64: e133.
 
[29]  Lerner A. Balanced polymorphism: a survival advantage in celiac disease. Editorial. Medical Hypotheses, 2011; 77: 1-2.
 
[30]  Lerner A. The last two millennias eco-catastrophes are the driving forces for the potential genetic advantage mechanisms in celiac disease. Med Hypotheses. 2011; 77: 773-6
 
[31]  Villella VR, Venerando A, Cozza G, Esposito S, Ferrari E, Monzani R, et al. A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J. 2019; 38. pii: e100101.
 
[32]  Tjernberg AR, Ludvigsson JF. Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection. Dig Dis Sci. 2014; 59: 1502-8.
 
[33]  Livne G, Lerner A, Hakim F, Eshach-Adiv O, Berkowitz D, Bentur L. Bronchial reactivity and fractional exhaled NO in Crohn's disease in the era of immunomodulating treatment. Acta Pediatr, 2012, 101; e399-404.
 
[34]  Kunz R, Minder M. COVID-19 pandemic: palliative care for elderly and frail patients at home and in residential and nursing homes. Swiss Med Wkly. 2020; 150: w20235.
 
[35]  Lerner A, Matthias T. Increased knowledge and awareness of celiac disease will benefit the elderly. Intern. J of Celiac Dis. 2015; 3: 112-114.
 
[36]  Chronic obstructive pulmonary disease group of Chinese Thoracic Society; Chronic obstructive pulmonary disease committee of Chinese Association of Chest Physician. Medical management and prevention instruction of chronic obstructive pulmonary disease during the coronavirus disease 2019 epidemic. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43: E034.
 
[37]  Lian J, Jin X, Hao S, Cai H, Zhang S, Zheng L, et al. Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan. Clin Infect Dis. 2020 Mar 25. pii: ciaa242.
 
[38]  Vardavas CI, Nikitara K. COVID-19 and smoking: A systematic review of the evidence. Tob Induc Dis. 2020; 18: 20.
 
[39]  Rubio-Tapia A, Kyle RA, Kaplan EL, Johnson DR, Page W, Erdtmann F, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009; 137: 88-93.
 
[40]  Rubio-Tapia A, Ludvigsson JF, Choung RS, Brantner TL, Rajkumar SV, Landgren O, Murray JA. Increased mortality among men aged 50 years old or above with elevated IgA anti-transglutaminase antibodies: NHANES III. BMC Gastroenterol. 2016; 16: 136.
 
[41]  Lerner A, Shoenfeld Y, Matthias T. A Review: Gluten ingestion side effects and withdrawal advantages in non-celiac autoimmune diseases. 2017, Nutritional rev. 2017; 75: 1046-1058.
 
[42]  Lerner A, O’Bryan T, Matthias T. Navigating the gluten-free diet boom: the dark side of gluten free diet. Frontiers Pediatrics. 2019; 7: Article 414.
 
[43]  Hujoel IA, Van Dyke CT, Brantner T, Larson J, King KS, Sharma A, et al. Natural history and clinical detection of undiagnosed coeliac disease in a North American community. Aliment Pharmacol Ther. 2018; 47: 1358-1366.
 
[44]  Gu J, Han B, Wang J. COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission. Gastroenterology. 2020 Mar 3. pii: S0016-5085(20)30281-X.
 
[45]  Lerner A, Ramesh A, Matthias T. David and Goliath war revival in the enteric viruses and microbiota struggle. Potential implication for celiac disease. Microorganisms, 2019; 7: 173.
 
[46]  Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 2004; 203: 622-30.
 
[47]  Sociedad Española de Patología Digestiva; Asociación Española de Gastroenterología. Recommendations by the SEPD and AEG, both in general and on the operation of gastrointestinal endoscopy and gastroenterology units, concerning the current SARS-CoV-2 pandemic (March, 18). Rev Esp Enferm Dig. 2020 Mar 23.
 
[48]  Repici A, Maselli R, Colombo M, Roberto Gabbiadini R, Spadaccini M, Anderloni A, et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. Gastrointest Endosc 202 Mar 13.
 
[49]  https://gi.org/2020/03/15/joint-gi-society-message-on-covid-19/ COVID-19 Clinical Insights for Our Community of Gastroenterologists and Gastroenterology Care Providers. Posted on March 15, 2020 by the American College of Gastroenterology News Team.