The Influence of Diabetes Mellitus on Lenticular Thickness

Shristi Shrestha^1, and Khem Raj Kaini¹

¹Department of Ophthalmology, Manipal Teaching Hospital, Pokhara, Nepal

Cite this paper:
Shristi Shrestha and Khem Raj Kaini. The Influence of Diabetes Mellitus on Lenticular Thickness. American Journal of Public Health Research. 2015; 3(5A):91-94. doi: 10.12691/ajphr-3-5A-19

Abstract

The prevalence of diabetes is increasing exponentially often causing an enormous public health burden. A hospital based observational study was undertaken and 144 type I diabetic subjects with equal number of non-diabetic controls were enrolled. The mean lens thickness, duration, fasting blood sugar, post prandial blood sugar and glycated hemoglobin were assessed. The crystalline lens was thicker in the diabetic group (4.33±0.38 mm vs 4.05±0.55 mm) which was statistically significant (p<0.001). There was a significant correlation between lens thickness and age (p<0.001, r=0.651) and between lens thickness and duration of diabetes (p<0.001, r=0.468). However, HBA1c and blood sugar levels had no significant influence on lenticular thickness.

Keywords:
lens thickness diabetes duration blood sugar level

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References:

[1]	Wild S, Reglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes. Diabetes Care. 2004; 27: 1047–1053.
[2]	Duke Elder S. Changes in refraction in diabetes mellitus. Br J Ophthalmol. 1925; 9: 167-187.
[3]	Fledelius HC, Fuchs J, Reck A. Refraction in diabetics during metabolic dysregulation, acute or chronic. With special reference to the diabetic myopia concept. Acta Ophthalmol (Copenh). 1990; 68 (3): 275-280.
[4]	Eva PR, Pascoe PT, Vaughan DG. Refractive changes in hyperglycemia: Hyperopia, not myopia. Acta Ophthalmol. 1982; 66: 500-505.
[5]	Giusti C. Transient hyperopic refractive changes in newly diagnosed juvenile diabetes. Swiss Med Wkly. 2003; 133 (13-14): 200-205.
[6]	Guzowski M, Wang JJ, Rochtchina E, Rose K, Mitchell P. Five-year refractive changes in an older population: the Blue Mountains Eye Study. Ophthalmology. 2003; 110: 1364-70.
[7]	Shimizu N, Nomura H, Ando F, Niino N, Miyake Y, Shimokata H. Refractive errors and factors associated with myopia in an adult Japanese population. Jpn J Ophthalmol. 2003; 47: 6-12.
[8]	Hoffer KJ. Axial dimension of the human cataractous lens. Arch Ophthalmol. 1993; 111: 914-918.
[9]	Bron AJ, Sparrow J, Brown NAP, Harding JJ, Blankytny R. The lens in diabetes. Eye. 1993; 7: 260-275.
[10]	Roters S, Hellmich M, Szurman P. Prediction of axial length on the basis of vitreous body length and lens thickness. Retrospective echobiometric study. J Cataract Refract Surg. 2002; 28: 853-859.
[11]	Saunders H. A longitudinal study of the age-dependence of human ocular refraction I. Age-dependent changes in the equivalent sphere. Ophthalmic Physiol Opt. 1986; 6: 39-46.
[12]	Slataper FJ. Age norms of refraction and vision. Arch Ophthalmol. 1950; 43: 466-481.
[13]	Moffat BA, Atchison DA, Pope JM. Explanation of the lens paradox. Optom Vis Sci. 2002; 79: 148-50.
[14]	Koretz JF, Kaufman PL, Neider MW, Goeckner PA. Accommodation and presbyopia in the human eye aging of the anterior segment. Vis Res. 1989; 29: 1685-1692.
[15]	Sparrow JM, Bron AJ, Brown NA, Neil HA. Biometry of crystalline lens in late onset diabetes: the importance of diabetic type. Br J Ophthalmology. 1992; 76: 428-433.
[16]	Logstrup N, Sjolie AK, Kyvik KO, Green A. Lens thickness and insulin dependent diabetes mellitus: a population based twin study. Br J Ophthalmol. 1996; 80: 405-408.
[17]	Li HY, Luo GC, Guo J, Liang Z. Effects of glycemic control on refraction in diabetic patients. Int J Ophthalmol. 2010; 3 (2): 158-160.
[18]	Fledelius HC, Miyamoto K. Diabetic myopia- is it lens induced? An oculometric study comprising ultrasound measurements. Acta Ophthalmologica. 1987; 65: 469-473.
[19]	Pierro L, Brancato R, Zaganelli E, Guarisco L, Calori G. Correlation of lens thickness with blood glucose control in diabetes mellitus. Acta Ophthalmologica Scandinavica. 1996; 74: 539-541.
[20]	Adnan, Pope JM, Sepehrband F, Suheimat M, Verkicharla PK, Kasthurirangan S, et al. Lens Shape and Refractive Index Distribution in Type I Diabetes. Invest Ophthalmol Vis Sci. 2015; 56(8): 4759-66.
[21]	SaitoY, Ohmi G, Kinoshita S, Nakamura Y, Ogawa K, Harino S, et al. Transient hyperopia with lens swelling at initial therapy in diabetes. British J Ophthalmology. 1993; 77: 145-148.
[22]	Weimer NGM, Dubbelman M, Kostense PJ, Ringens PJ, Polak BCP. The influence of DM Type 1 and 2 on the Thickness, Shape, and Equivalent Refractive Index of the Human Crystalline Lens. Ophthalmology. 2008; 115 (10): 1679-86.
[23]	Weimer NGM, Dubbelman M, Hermans EA, Ringens PJ, Polak BCP. Changes in the Internal Structure of the Human Crystalline Lens with Diabetes Mellitus Type 1 and Type 2. Ophthalmology. 2008; 115 (11): 2017-23.
[24]	Sparrow JM, Bron AJ, Brown AP, Neil HAW. Biometry of crystalline lens in early onset diabetes. Br J Ophthalmology. 1990; 74: 654-660.