American Journal of Medical Sciences and Medicine
ISSN (Print): 2327-6681 ISSN (Online): 2327-6657 Website: https://www.sciepub.com/journal/ajmsm Editor-in-chief: Apply for this position
Open Access
Journal Browser
Go
American Journal of Medical Sciences and Medicine. 2015, 3(6), 84-105
DOI: 10.12691/ajmsm-3-6-3
Open AccessArticle

Correlation between P Wave Dispersion, QRS Duration & QT Dispersion in Hospital Events in Cases of Acute Coronary Syndrome

Mahmoud Fekry Hassan Hassebo1, , Tarek Hussein El Badawy2, Muhammad Nasr eldin El Sayed3 and Mohamed Mostafa Abd El Salam Megahed4

1Alexandria University Hospitals, Department of Critical Care Medicine, Faculty of Medicine, University of Alexandria

2Cardiology and Angiology, Faculty of Medicine, University of Alexandria

3Critical Care Medicine, Alexandria University Hospitals

4Critical Care Medicine, Faculty of Medicine, University of Alexandria

Pub. Date: December 24, 2015

Cite this paper:
Mahmoud Fekry Hassan Hassebo, Tarek Hussein El Badawy, Muhammad Nasr eldin El Sayed and Mohamed Mostafa Abd El Salam Megahed. Correlation between P Wave Dispersion, QRS Duration & QT Dispersion in Hospital Events in Cases of Acute Coronary Syndrome. American Journal of Medical Sciences and Medicine. 2015; 3(6):84-105. doi: 10.12691/ajmsm-3-6-3

Abstract

Back Ground: The acute coronary syndromes encompass a spectrum of unstable angina to transmural myocardial infarction. The definition of acute coronary syndrome depends on the specific characteristics of each element of the triad of clinical presentation, electrocardiographic changes and biochemical cardiac markers. Objectives: To assess Correlation between P wave dispersion, QRS duration & QT dispersion in hospital events in patients with acute coronary syndrome (ACS). Methods: This prospective study was conducted on 60 patients with acute coronary syndrome admitted to critical care units of Alexandria University Hospitals from first of January 2012 to end of August 2012. An informed consent was taken from relatives of every patient included in the study. This study was approved by ethical committee of Alexandria Faculty Of Medicine. RESULTS: During the observation up to 5 days, 1 patient (1.6%) developed AF. There was no significant correlation between P wave dispersion(PD) in the three studied groups& No significant relation between it & the whole complications developed in failed thrombolysis group (p> 0.05). PD alone couldn’t predict AF in this study, as the mean was 20.0 milliseconds, which was too small to predict AF alone. There was no significance difference between QRS duration in the three groups (unstable angina, successful thrombolysis and failed thrombolysis respectively with mean value (75.7 ± 14.02, 75.2 ± 10.88, 73.36± 8.81) (p> 0.05) & the relationship between the QRS duration and the development of complications was non-significant in this study. This study showed that there was a significant relation among the three groups & highly significant correlation between QTD duration and prediction of complications. It was clear that ICU length of stay was longer in patients with failed thrombolysis in comparison with the other two groups (p<0.05). Conclusions: 1- Importance of measurementsof QT Dispersion to patients with acute coronary syndrome especially at admission. 2- Failed thrombolysis patients should be under close observation and monitoring till another option is available like coronary intervention.

Keywords:
P wave dispersion QRS duration & QT dispersion

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. Sep 2000; 36(3):959-69.
 
[2]  Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011
 
[3]  Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med. 1996; 335(18):1342-9.
 
[4]  Heidenreich PA, Alloggiamento T, Melsop K, McDonald KM, Go AS, Hlatky MA. The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis. J Am Coll Cardiol. 2001; 38(2):478-85.
 
[5]  Scheuermeyer FX, Innes G, Grafstein E, et al. Safety and Efficiency of a Chest Pain Diagnostic Algorithm With Selective Outpatient Stress Testing for Emergency Department Patients With Potential Ischemic Chest Pain. Ann Emerg Med. 2012.
 
[6]  Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction:J Am Coll Cardiol. 2007; 50(7):e1-e157.
 
[7]  Venge P, Ohberg C, Flodin M, Lindahl B. Early and late outcome prediction of death in the emergency room setting by point-of-care and laboratory assays of cardiac troponin I. Am Heart J. 2010;160(5):835-41.
 
[8]  Misra D, Leibowitz K, Gowda RM, Shapiro M, Khan IA. Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures: a meta-analysis. Clin Cardiol. 2004; 27(11):607-10.
 
[9]  Charpentier S, Cournot M, Lauque D, et al. Usefulness of initial glucose level to improve acute coronary syndrome diagnosis in the emergency department. Emerg Med J. 2011; 28(7):564-8.
 
[10]  de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, et al. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med. 2001; 345(14):1014-21.
 
[11]  James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, et al. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy. Circulation. 2003; 108(3):275-81.
 
[12]  Cavusoglu E, Marmur JD, Hojjati MR, et al. Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome. Am J Med. 2011; 124(8):724-30.
 
[13]  Katritsis DG, Siontis GC, Kastrati A, van't Hof AW, Neumann FJ, Siontis KC, et al. Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes. Eur Heart J. 2011; 32(1):32-40.
 
[14]  Nabi F, Chang SM, Pratt CM, Paranilam J, Peterson LE, Frias ME, et al. Coronary artery calcium scoring in the emergency department: identifying which patients with chest pain can be safely discharged home. Ann Emerg Med. 2010; 56(3):220-9.
 
[15]  Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 2010; 153(7):425-34.
 
[16]  Miller CD, Hwang W, Hoekstra JW, Case D, Lefebvre C, Blumstein H, et al. Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med. 2010; 56(3): 209-219.
 
[17]  Mehta SR, Yusuf S. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Eur Heart J. 2000; 21(24):2033-41.
 
[18]  Thadani U, Opie LH. Nitrates for unstable angina. Cardiovasc Drugs Ther. 1994; 8(5):719-26.
 
[19]  Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ. 1994; 308(6921):81-106.
 
[20]  [Guideline] Wright RS, Anderson JL, Adams CD, Bridges CR, Casey DE Jr, Ettinger SM, et al. 2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients With Unstable Angina/ Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011; 123(18):2022-60.
 
[21]  Squizzato A, Keller T, Romualdi E, Middeldorp S. Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. Cochrane Database Syst Rev. 2011.
 
[22]  Simon T, Steg PG, Gilard M, Blanchard D, Bonello L, Hanssen M, et al. Clinical Events as a Function of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genotype in a Large Nationwide Cohort of Acute Myocardial Infarction: Results From the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry. Circulation. 2011; 123(5):474-82.
 
[23]  [Best Evidence] Morrow DA, Wiviott SD, White HD, Nicolau JC, Bramucci E, Murphy SA, et al. Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: an application of the classification system from the universal definition of myocardial infarction. Circulation. 2009; 119(21): 2758-64.
 
[24]  James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, et al. Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2009;v157(4):599-605.
 
[25]  [Best Evidence] Kastrati A, Mehilli J, Neumann FJ, Dotzer F, ten Berg J, Bollwein H, et al. Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA. 2006; 295(13):1531-8.
 
[26]  Roffi M, Moliterno DJ, Meier B, Powers ER, Grines CL, DiBattiste PM, et al. Impact of different platelet glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous coronary intervention: Do Tirofiban and ReoPro Give Similar Efficacy Outcomes Trial (TARGET) 1-year follow-up. Circulation. 2002; 105(23):2730-6.
 
[27]  Roe MT, Harrington RA, Prosper DM, Pieper KS, Bhatt DL, Lincoff AM, et al. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease.The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators. Circulation. 2000; 102(10):1101-6.
 
[28]  Théroux P, Alexander J Jr, Pharand C, Barr E, Snapinn S, Ghannam AF, et al. Glycoprotein IIb/IIIa receptor blockade improves outcomes in diabetic patients presenting with unstable angina/non-ST-elevation myocardial infarction: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) study. Circulation. 2000; 102(20):2466-72.
 
[29]  Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA. 1996;276(10):811-5.
 
[30]  Steg PG, Jolly SS, Mehta SR, Afzal R, Xavier D, Rupprecht HJ, et al. Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. JAMA. 2010; 304(12):1339-49.
 
[31]  Lev EI, Hasdai D, Scapa E, Tobar A, Assali A, Lahav J, et al. Administration of eptifibatide to acute coronary syndrome patients receiving enoxaparin or unfractionated heparin: effect on platelet function and thrombus formation. J Am Coll Cardiol. 2004; 43(6):966-71.
 
[32]  Van Rees Vellinga TE, Peters RJ, et al. Efficacy and safety of fondaparinux in patients with ST-segment elevation myocardial infarction across the age spectrum. Results from the Organization for the Assessment of Strategies for Ischemic Syndromes 6 (OASIS-6) trial. Am Heart J. 2010; 160(6):1049-55.
 
[33]  Jolly SS, Faxon DP, Fox KA, et al. Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial. J Am Coll Cardiol. 2009; 54(5):468-76.
 
[34]  Sørensen JT, Terkelsen CJ, Nørgaard BL, Trautner S, Hansen TM, Bøtker HE, et al. Urban and rural implementation of pre-hospital diagnosis and direct referral for primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction. Eur Heart J. 2011; 32(4):430-6.
 
[35]  Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, et al. Bivalirudin for patients with acute coronary syndromes. N Engl J Med. Nov 23 2006; 355(21):2203-16.
 
[36]  Anderson RH, Ho SY, Wharton J, Becker AE. Gross anatomy and microscopy of the conducting system. In: Mandel WJ, ed. Cardiac arrhythmias: their mechanisms, diagnosis, and management. Philadelphia: JB Lippincott, 1995:13-54.
 
[37]  Olson CW, Warner RA, Wagner GS, Selvester RH. A dynamic three-dimensional display of ventricular excitation and the generation of the vector and electrocardiogram. J Electrocardiol 2001;34(suppl):7-15
 
[38]  Macfarlane PW, Lawrie TD, eds. Comprehensive electrocardiology: theory and practice in health and disease. 1st ed. Vol. 1, ed. PW Macfarlane, TDV Lawrie, pp. 407-57, New York: Pergamon Press, 1989.
 
[39]  Surawicz B. Stretching the limits of the electrocardiogram's diagnostic utility. J Am Coll Cardiol 1998;32:483-485.
 
[40]  Barold SS, Fisch C, Schamroth L, Wellens HJJ. Richard Langendorf: 1908-1987. Pacing Clin Electrophysiol 1988; 11: 1242-1247.
 
[41]  Anderson ST, Pahlm O, Selvester RH, et al. Panoramic display of the orderly sequenced 12-lead ECG. J Electrocardiol 1994; 27:347- 352.
 
[42]  Reinig MG, Harizi R, Spodick DH. Electrocardiographic T- and U-wave discordance. Ann Noninvasive Electrocardiol 2005; 10:41-46.
 
[43]  Surawicz B. U wave: facts, hypotheses, misconceptions, and misnomers. J Cardiovasc Electrophysiol 1998;9:1117-1128.
 
[44]  Antzelevitch C, Shimizu W, Yan GX, et al. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol 1999; 10:1124-1152.
 
[45]  Viskin S, Rosovski U, Sands AJ, et al. Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one. Heart Rhythm 2005;2:569-574.
 
[46]  Bidoggia H, Maciel JP, Capalozza N, et al. Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am Heart J 2000;140:678-683.
 
[47]  Sarma JSM, Sarma RJ, Bilitch M, et al. An exponential formula for heart rate dependence of QT interval during exercise and cardiac pacing in humans: reevaluation of Bazett's formula. Am J Cardiol 1984;54:103-108.
 
[48]  Kaplan JD, Evans T Jr, Foster E, et al. Evaluation of electrocardiographic criteria for right atrial enlargement by quantitative two-dimensional echocardiography. J Am Coll Cardiol 1994;23:747-752.
 
[49]  Scott CC, Leier CV, Kilman JW, et al. The effect of atrial histology and dimension on P wave morphology. J Electrocardiol 1983;16:363-366.
 
[50]  Alpman A, Galdal M, Berkalp B, et al. Importance of notching and slurring of the resting QRS complex in the diagnosis of coronary artery disease. J Electrocardiol 1995;28:199-208.
 
[51]  Walston A, Brewer DL, Kitchens CS, Krook JE. The electrocardiographic manifestations of spontaneous left pneumothorax. Ann Intern Med 1974; 80:375-379.
 
[52]  Goldberger A. Normal and noninfarct Q waves. Cardiol Clin 1987;5:357-366.
 
[53]  Bar FW, Brugada P, Dassen WR, et al. Prognostic value of Q waves, R/S ratio, loss of R wave voltage, ST-T segment abnormalities, electrical axis, low voltage and notching: correlation of electrocardiogram and left ventriculogram. J Am Coll Cardiol 1984;4:17-27.
 
[54]  Schouten EG, Dekker JM, Meppelink P, et al. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 1991;84:1516-1523.
 
[55]  Bijl M, Verheugt FW. Extreme QT prolongation solely due to reversible myocardial ischemia in single-vessel coronary disease. Am Heart J 1992; 123:524-526.
 
[56]  Barletta G, Lazzeri C, Franchi F, et al. Hypertrophic cardiomyopathy: electrical abnormalities detected by the extended-length ECG and their relation to syncope. Int J Cardiol 2004;97:43-48.
 
[57]  Oka H, Mochio S, Sato K, Isogai Y. Correlation of altered QT interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy. Eur Neurol 1994;34:23-29.
 
[58]  Hanrahan JP, Choo PW, Carlson W, et al. Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. Ann Epidemiol 1995;5:201-209.
 
[59]  Malik M. Errors and misconceptions in ECG measurement used for the detection of drug induced QT interval prolongation. J Electrocardiol 2004; 37(suppl):25-33.
 
[60]  Pacher P, Kecskemeti V. Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Curr Pharm Des 2004; 10:2463-2475.
 
[61]  Dan M. Roden, Drugs that prolong the QT interval and/or induce torsade de pointes. N Engl J Med 2004; 350:1013-22.
 
[62]  Moss AJ, Zareba W, Benhorin J, et al. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation 1995; 92: 2929-2934.
 
[63]  Malfatto G, Beria G, Sala S, et al. Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic QT syndrome. J Am Coll Cardiol 1994; 23:296-301.
 
[64]  Rosenbaum MB, Acunzo RS. Pseudo 2:1 atrioventricular block and T wave alternans in long QT syndromes. J Am Coll Cardiol 1991;18:1363-1366.
 
[65]  Zareba W, Moss AJ, le Cessie S, Hall WJ. T wave alternans in idiopathic long QT syndrome. J Am Coll Cardiol 1994;23:1541-1546.
 
[66]  Schimpf R, Wolpert C, Gaita F, et al. Short QT syndrome. Cardiovasc Res 2005;67:357-366.
 
[67]  Franz MR, Bargheer K, Costard-Jäckle A, et al. Human ventricular repolarization and T wave genesis. Prog Cardiovasc Dis 1991;33:369-384.
 
[68]  Alfonso F, Nihoyannopoulos P, Stewart J, et al. Clinical significance of giant negative T waves in hypertrophic cardiomyopathy. J Am Coll Cardiol 1990;15:965-971.
 
[69]  Libbus I, Rosenbaum DS. Remodeling of cardiac repolarization: mechanisms and implications of memory. Card Electrophysiol Rev 2002;6:302-310.
 
[70]  Sgarbossa EB, Meyer PM, Pinski SL, et al. Negative T waves shortly after ST-elevation acute myocardial infarction are a powerful marker for improved survival. Am Heart J 2000;140:385-394.
 
[71]  Tamura A, Nagase K, Mikuriya Y, Nasu M. Significance of spontaneous normalization of negative T waves in infarct-related leads during healing of anterior wall acute myocardial infarction. Am J Cardiol 1999;84;1341-1344.
 
[72]  Lancellotti P, Gerard PL, Kulbertus HE, Pierard LA. Persistent negative T waves in the infarct-related leads as an independent predictor of poor long-term prognosis after acute myocardial infarction. Am J Cardiol 2002;90: 833-837.
 
[73]  Beckerman J, Yamazaki T, Myers J, et al. T-wave abnormalities are a better predictor of cardiovascular mortality than ST depression on the resting electrocardiogram. Ann Noninvasive Electrocardiol 2005;10:146-151.
 
[74]  Sclarovsky S, ed. Electrocardiography of acute myocardial ischemic syndromes. London: Martin Dunitz, 1999.
 
[75]  Herrick JB. An intimate account of my early experience with coronary thrombosis. Am Heart J 1944;27:1-18.
 
[76]  Birnbaum Y, Maynard C, Wolfe S, et al. Terminal QRS distortion on admission is better than ST-segment measurements in predicting final infarct size and assessing the potential effect of thrombolytic therapy in anterior wall acute myocardial infarction. Am J Cardiol 1999;84:530-534.
 
[77]  Sievers B, John B, Brandts B, et al. How reliable is electrocardiography in differentiating transmural from non-transmural myocardial infarction? A study with contrast magnetic resonance imaging as gold standard. Int J Cardiol 2004;97:417-423.
 
[78]  Reimer KA, Ideker RE. Myocardial ischemia and infarction: anatomic and biochemical substrates for ischemic cell death and ventricular arrhythmias. Hum Pathol 1987;18:462-475.
 
[79]  Essen RV, Merx W, Effert S. Spontaneous course of ST-segment elevation in acute myocardial infarction. Circulation 1979;59:105-112.
 
[80]  Bren GB, Wasserman AG, Ross AM. The electrocardiogram in patients undergoing thrombolysis for myocardial infarction. Circulation 1987; 76(suppl II):II18-II24.
 
[81]  Justis DL, Hession WT. Accuracy of 22-lead ECG analysis for diagnosis of acute myocardial infarction and coronary artery disease in the emergency department: a comparison with 12-lead ECG. Ann Emerg Med 1992;21:1-9.
 
[82]  Wilson FN, Johnston FD, Rosenbaum F, et al. The precordial electrocardiogram. Am Heart J 1944;27:19-85.
 
[83]  Elko PP, Weaver WD, Kudenchuk P, Rowlandson I. The dilemma of sensitivity versus specificity in computer-interpreted acute myocardial infarction. J Electrocardiol 1992;24(suppl):2-7.
 
[84]  Cairns CB, Niemann JT, Selker HP, Laks MM. Computerized version of the time-insensitive predictive instrument. J Electrocardiol 1992;24(suppl):46-49.
 
[85]  O'Rourke MF, Cook A, Carroll G, et al. Accuracy of a portable interpretive ECG machine in diagnosis of acute evolving myocardial infarction. Aust NZ J Med 1992;22:9-13.
 
[86]  Brady WJ, Perron AD, Martin ML, et al. Cause of ST segment abnormality in ED chest pain patients. Am J Emerg Med 2001;19:25-28.
 
[87]  Moon JC, De Arenaza DP, Elkington AG, et al. The pathologic basis of Q-wave and non-Q-wave myocardial infarction: a cardiovascular magnetic resonance study. J Am Coll Cardiol 2004;44:554-560.
 
[88]  Kaandorp TA, Bax JJ, Lamb HJ, et al. Which parameters on magnetic resonance imaging determine Q waves on the electrocardiogram? Am J Cardiol 2005;95:925-929.
 
[89]  Park SE, Tani A, Minamino T, et al. Coronary angiographic features within 48 hours from onset of non Q wave myocardial infarction with R wave regression and no ST segment depression. Cardiology 1990;77:121-129.
 
[90]  Barbagelata A, Califf RM, Sgarbossa EB, et al. Thrombolysis and Q-wave versus non Q-wave first acute myocardial infarction: a GUSTO-I substudy. J Am Coll Cardiol 1997;29:770-777.
 
[91]  Raitt MH, Maynard C, Wagner GS, et al. Appearance of abnormal Q waves early in the course of acute myocardial infarction: implications for efficacy of thrombolytic therapy. J Am Coll Cardiol 1995;25:1084-1088.
 
[92]  Krucoff MW, Green CE, Satler LF, et al. Noninvasive detection of coronary artery patency using continuous ST-segment monitoring. Am J Cardiol 1996;57:916-921.
 
[93]  Brodie BR, Stuckey TD, Hansen C, et al. Relation between electrocardiographic ST-segment resolution and early and late outcomes after primary percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol 2005;95:343-348.
 
[94]  Zeymer U, Schroder K, Wegscheider K, et al. ST resolution in a single electrocardiographic lead: a simple and accurate predictor of cardiac mortality in patients with fibrinolytic therapy for acute ST-elevation myocardial infarction. Am Heart J 2005;149:91-97.
 
[95]  De Luca G, Maas AC, van't Hof AW, et al. Impact of ST-segment depression resolution on mortality after successful mechanical reperfusion in patients with ST-segment elevation acute myocardial infarction. Am J Cardiol 2005;95:234-236.
 
[96]  Chou TC. Myocardial infarction, myocardial injury, and myocardial ischemia. In: Chou TE, ed. Electrocardiography in clinical practice: adult and pediatric. Philadelphia: WB Saunders, 1996:121-213.
 
[97]  Sgarbossa EB, Birnbaum Y, Parrillo JE. ECG diagnosis of acute myocardial infarction: current concepts for the clinician. Am Heart J 2001,141:507-517.
 
[98]  Richardson K, Engel G, Yamazaki T, et al. Electrocardiographic damage scores and cardiovascular mortality. Am Heart J 2005;149:458-463.
 
[99]  Svensson L, Axelsson C, Nordlander R, Herlitz J. Prehospital identification of acute coronary syndrome/myocardial infarction in relation to ST elevation. Int J Cardiol 2005;98:237- 244.
 
[100]  Hansen, DE, Craig, CS, Hondeghem, LM. Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of electromechanical feedback. Circulation 1990; 81:1094.
 
[101]  Popovic, AD, Neskovic, AN, Pavlovski, K, et al. Association of ventricular arrhythmias with left ventricular remodelling after myocardial infarction. Heart 1997; 77:423.
 
[102]  Janse, MJ, Wit, AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischaemia and infarction. Physiol Rev 1989; 69:1049.
 
[103]  Yunus, A, Gillis, AM, Duff, HJ, et al. Increased precordial QTc dispersion predicts ventricular fibrillation during acute myocardial infarction. Am J Cardiol 1996; 78:706.
 
[104]  Endoh, Y, Kasanuki, H, Ohnishi, S, et al. Influence of early coronary reperfusion on QT interval dispersion after acute myocardial infarction. Pacing Clin Electrophysiol 1997; 20:1646.
 
[105]  Iwasaki, T, Suzuki, T, Tateno, M, et al. Dual-tracer autoradiography with thallium-201 and iodine-125-metaiodobenzylguanidine in experimental myocardial infarction of rat. J Nucl Med 1996; 37:680.
 
[106]  Nishimura, T, Oka, H, Sago, M, et al. Serial assessment of denervated but viable myocardium following acute myocardial infarction in dogs using iodine-123 metaiodobenzylguanidine and thallium-201 chloride myocardial single photon emission tomography. Eur J Nucl Med 1992; 19:25.
 
[107]  Stanton, MS, Tuli, MM, Radtke, NL, et al. Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine. J Am Coll Cardiol 1989; 14:1519.
 
[108]  Inoue, H, Zipes, DP. Results of sympathetic denervation in the canine heart: Supersensitivity that may be arrhythmogenic. Circulation 1987; 75:877.
 
[109]  Hartikainen, J, Kuikka, J, Mantysaari, M, et al. Sympathetic reinnervation after acute myocardial infarction. Am J Cardiol 1996; 77:5.
 
[110]  Goldstein, JA, Butterfield, MC, Ohnishi, Y, et al. Arrhythmogenic influence of intracoronary thrombosis during acute myocardial ischemia. Circulation 1994; 90:139.
 
[111]  Coronel, R, Wilms-Schopman, FJG, Janse, MJ. Profibrillatory effects of intracoronary thrombus in acute regional ischemia of the in situ porcine heart. Circulation 1997; 96:3985.
 
[112]  McHowat, J, Corr, PB. Thrombin-induced release of lysophosphatidylcholine from endothelial cells. J Biol Chem 1993; 268:15605.
 
[113]  Clarkson, CW, Sawicki, G. The effects of lysophosphatidylcholine, a toxic metabolite of ischemia, on the components of cardiac excitability in sheep Purkinje fibers. Circ Res 1981; 49:16.
 
[114]  Clarkson, CW, Ten Eick, RE. On the mechanism of lysophosphatidylcholine-induced depolarization of cat ventricular myocardium. Circ Res 1983; 52:534.
 
[115]  Opie, LH, Coetzee, WA. Role of calcium ions in reperfusion arrhythmias: Relevance to pharmacologic intervention. Cardiovasc Drugs Ther 1988; 2:623.
 
[116]  Coetzee, WA, Opie, LH. Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle. Circ Res 1987; 61:157.
 
[117]  Hagar, JM, Kloner, RA. Reperfusion arrhythmias: Experimental and clinical aspects. The Age of Reperfusion 1990; 2:1.
 
[118]  Eric J. Topol, Peter Lanzer ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; 2:349.
 
[119]  Gruppo Italiano per lo Studio della Streptochinasi nell'infarto Miocardico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986; 1:397.
 
[120]  Yoshida, Y, Hirai, M, Yamada, T, et al. Antiarrhythmic efficacy of dipyridamole in treatment of reperfusion arrhythmias : evidence for cAMP-mediated triggered activity as a mechanism responsible for reperfusion arrhythmias [In Process Citation]. Circulation 2000; 101:624.
 
[121]  Rosiak M, Bolinska H, Ruta J. P wave dispersion and P wave duration on SAECG in predicting atrial fibrillation in patients with acute myocardial infarction. Annuals ofnon invasive electrocardiography 2002;7(4) :363-368.
 
[122]  Fahad B, Salem A, Andrew T.  Yan, QRS prolongation in patients with acute coronary syndromes. Am Heart J 2010; 159(4): 593-8.
 
[123]  Pekdemir M, Karaca I, Cevik Y, Yanturali S, Ilkay E. The diagnostic value of QT dispersion for acute coronary syndrome in patients presenting with chest pain and nondiagnostic initial electrocardiograms Mt Sinai J Med 2006; 73(5):813-7.
 
[124]  Torres M, Moayedi S. Evaluation of the acutely dyspneic elderly patient. Clin Geriatr. Med 2007; 23(2):307-25.
 
[125]  Grech ED, Ramsdale DR. Acute coronary syndrome: unstable angina and non-ST segment elevation myocardial infarction. BMJ 2003; 326(7401):1259-61.
 
[126]  Achar SA, Kundu S, Norcross WA. Diagnosis of acute coronary syndrome". Am Fam Physician 2005; 72(1):119-26.
 
[127]  Josephson ME, Kastor JA, Morganroth J. Electrocardiographic left atrial enlargement.Electrophysiologic, echocardiographic and hemodynamic correlates. Am J Cardiol 1977; 39:967-71.
 
[128]  Dilaveris PE, Gialafos EJ, Sideris SK, Theopistou AM, Andrikopoulos GK, Kyriakidis M,Gialafos JE, et al. Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation. Am Heart J 1998; 135:733-8.
 
[129]  Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Papanikolaou V, Poralis K,Gialafos JE. Clinical and electrocardiographic predictors of recurrent atrial fibrillation. Pacing Clin Electrophysiol 2000; 23:352-8.
 
[130]  Bitzen A, Sternickel K, Lewalter T, Schwab JO, Yang A, Schrickel JW, Linhart M, et al. Automatic p wave analysis over 24 hours in patients with paroxysmal or persistent atrial fibrillation. Ann Noninvasive Electrocardiol 2007; 12:306-15.
 
[131]  Cheema AN, Ahmed MW, Kadish AH, Goldberger JJ. Effects of autonomic stimulation and blockade on signal-averaged P-wave duration. J Am Coll Cardiol 1995; 26:497-502.
 
[132]  Meta-Analysis of P-Wave Dispersion Values in Healthy Individuals: The Influence of Clinical CharacteristicAnnals of Noninvasive Electrocardiology 2012; 17(1): 28-35.
 
[133]  Dilaveris E, Andrikopoulos GK, Metaxas G, et al. Effects of ischemia on P wave dispersion and maximum P wave duration during spontaneous anginal episodes. Pacing Clin Electrophysiol 1999; 22: 1640.
 
[134]  Petrina M, Goodman SG, Eagle KA. The 12-lead electrocardiogram as a predictive tool of mortality after acute myocardial infarction: current status in an era of revascularization and reperfusion. Am Heart J 2006; 152:11-8.
 
[135]  Brenyo A, Zaręba W. Prognostic significance of QRS duration and morphology. Cardiol J 2011; 18(1):8-17.
 
[136]  Suzuki M, Nishizaki M, Arita M, et al. Increased QT dispersion in patients with vasospastic angina. Circulation 1998; 98:435-40.
 
[137]  Janse MJ, Wit AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev 1989; 69:1049-169.
 
[138]  Craig M. Lilly, Shawn Cody, Huifang Zhao, et al. Hospital Mortality, Length of Stay, and Preventable Complications Among Critically Ill Patients Before and After Tele-ICU Reengineering of Critical Care Processes, JAMA 2011; 305:21.