Recurrent Hematuria in a Patient with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Renal Transplantation: A Case Report

Madeleidis Lopez Leon¹, Sahar S. Abdelmoneim^1, , Milenis Lopez Leon¹, Sandy Espinosa Hernandez¹, Mohsin M. Idrees¹, Francisco Lopez Bermudez¹, Lazaro U. Suarez Ross¹, Rishbha Dua¹ and Odalys Frontela¹

¹Division of Internal Medicine, Larkin Palm Spring Community Hospital, Hialeah, Florida

Cite this paper:
Madeleidis Lopez Leon, Sahar S. Abdelmoneim, Milenis Lopez Leon, Sandy Espinosa Hernandez, Mohsin M. Idrees, Francisco Lopez Bermudez, Lazaro U. Suarez Ross, Rishbha Dua and Odalys Frontela. Recurrent Hematuria in a Patient with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Renal Transplantation: A Case Report. American Journal of Medical Sciences and Medicine. 2022; 10(3):78-81. doi: 10.12691/ajmsm-10-3-2

Abstract

Hematuria occurrence in autosomal dominant polycystic kidney disease (ADPKD) is common and can be a manifestation of cyst bleeding. Patients with ADPKD who receive kidney transplantation can present with recurrent hematuria. Malignancy, urinary tract infections, calculus obstruction or any recent diagnostic or interventional procedures can all manifest with hematuria. Knowledge of the precipitating factors and clinical presentation in those patients will help practicing internists in performing an appropriate evaluation and management of these entities and their complications, as well as execute a timely referral to subspecialists for native kidney nephrectomies when indicated. We herein, present a case of 72-years-old female, with APKD who received kidney transplantation 14 years ago, presenting with repeated hospital admissions with flank pain and recurrent hematuria. She had experienced multiple admissions with hematuria, most likely caused by native kidney recurrent cyst bleedings.

Keywords:
hematuria polycystic and renal transplantation

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters D JM, Torres VE. Polycystic kidney disease. Nat Rev Dis Primers. 2018 Dec 6; 4(1): 50.
[2]	Nobakht N, Hanna RM, Al-Baghdadi M, Ameen KM, Arman F, Nobahkt E, Mohammad Kamgar M, Rastogi A. Advances in Autosomal Dominant Polycystic Kidney Disease: A Clinical Review Kidney Med. 2020 Mar-Apr; 2(2): 196-208.
[3]	Patel P, Horsfield C, Compton F, Taylor J, Koffman G, Olsburgh J. Native nephrectomy in transplant patients with autosomal dominant polycystic kidney disease. Ann R Coll Surg Engl. 2011 Jul; 93(5): 391-5.
[4]	Perumareddi P, Trelka DP. Autosomal Dominant Polycystic Kidney Disease. Prim Care. 2020 Dec; 47(4): 673-689.
[5]	Neeff HP, Pisarski P, Tittelbach-Helmrich D, Karajanev K, Neumann HP, Hopt UT, Drognitz O. One hundred consecutive kidney transplantations with simultaneous ipsilateral nephrectomy in patients with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2013 Feb; 28(2): 466-71.
[6]	Dunn MD, Portis AJ, Elbahnasy AM et al., Laparoscopic nephrectomy in patients with end-stage renal disease and autosomal dominant polycystic kidney disease. The American Journal of Kidney Diseases. 2000 Apr;35(4):720-5.
[7]	Veroux M, Zerbo D, Basile G, Gozzo C, Sinagra N, Giaquinta A, Sanfiorenzo A, Veroux P. Simultaneous Native Nephrectomy and KidneyTransplantation in Patients With Autosomal Dominant Polycystic Kidney Disease. PLoS One. 2016; 11(6): e0155481.
[8]	Wang Z, Vathsala A, Ho Yee Tiong HY. Hematuria in Postrenal Transplant Patients. Biomed Res Int. 2015: 292034.
[9]	Sulikowski T., Tejchman K., Zietek Z. et al., Experience with autosomal dominant polycystic kidney disease in patients before and after renal transplantation: a 7-year observation,” Transplantation Proceedings 2009 Jan-Feb; 41(1): 177-80.
[10]	Tsung-Yin T,Cheng-Hsu C, Ming-Ju Wu M, Tsai S-F. Outcomes of Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: Our Experience Based on 35-Years Follow-Up. Diagnostics 2022, 12(5), 1174.
[11]	Bellini MI, Charalmpidis S, Brookes P, Hill P, Dor F, Papalois V. Bilateral Nephrectomy for Adult Polycystic Kidney Disease Does Not Affect the Graft Function of Transplant Patients and Does Not Result in Sensitization. Biomed Res Int. 2019: 7423158.