Intrauterine Vertical Transmission of SARS-CoV-2. What do We Learn from Evolving Literature so Far?

Simon Byonanuwe^1, , Robinson Ssebuufu¹, Yarine Fajardo¹ and Emmanuel Nzabandora¹

¹Faculty of Clinical Medicine and Dentistry, Kampala International University, Uganda

Cite this paper:
Simon Byonanuwe, Robinson Ssebuufu, Yarine Fajardo and Emmanuel Nzabandora. Intrauterine Vertical Transmission of SARS-CoV-2. What do We Learn from Evolving Literature so Far?. American Journal of Medical Sciences and Medicine. 2020; 8(4):149-152. doi: 10.12691/ajmsm-8-4-2

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains at every one’s toes all over the world with every aspect of life affected. Infection reports of SARS-CoV-2 in pregnancy seem to be on the raise in certain parts of the world. There is an apparent concern of possibility of intrauterine vertical transmission of this pathogen. This review aimed to analyze what is in the scientific literature so far in regard to the possibility of intrauterine vertical transmission of SARS-CoV-2 so as to offer suggestions that might contribute to future research and awareness of possible intrauterine transmission of SARS-CoV-2. It was noted that although seemingly sporadic, the published cases so far call for urgent need for a standard protocol for diagnosis of intrauterine vertical transmission of SARS-CoV-2, clear understanding of the mechanisms and risk factors for the transmission, as well as efforts towards ensuring accessibility of the necessary diagnostics for suspected intrauterine infections.

Keywords:
COVID-19 intrauterine vertical transmission SARS-CoV-2

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References:

[1]	Cristina A, Ribeiro C, Leal V. Is SARS-CoV-2 vertically transmitted? Front Pediatr. 2020; 8(276): 1-5.
[2]	Mulvey JJ, Magro CM, Ma LX, Nuovo GJ, Baergen RN. Analysis of complement deposition and viral RNA in placentas of COVID-19 patients. Ann Diagn Pathol. 2020; 46(2020): 1-4.
[3]	Situation report-178. Data as received by WHO from national authorities by 10:00 CEST 16 July 2020. Coronavirus disease (COVID-19). World Heal Organ. 2020; (July).
[4]	Karimi-zarchi M, Neamatzadeh H, Alireza S. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: A review. Fetal Pediatr Pathol[Internet]. 2020; 0(0): 1-5.
[5]	Harishchandra A, Deepali N, Kapote S, Fonseca M, Chavan N, Mayekar R. Impact of the coronavirus infection in pregnancy: A preliminary study of 141 patients. J Obstet Gynecol India [Internet]. 2020; (123456789).
[6]	Silasi M, Cardenas I, Racicot K, Kwon J-Y, Aldo P, Mor G. Viral infections during pregnancy. Am J Reprod Immunol. 2016; 73(3): 199-213.
[7]	Arora N, Sadovsky Y, Dermody TS, Coyne CB. Microbial vertical transmission during human pregnancy. Cell Host Microbe. 2018; 21(5): 561-7.
[8]	Zhao X, Jiang Y, Zhao Y, Xi H, Liu C, Qu F, et al. Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening. Eur J Clin Microbiol Infect Dis. 2020; 39(1): 1209-20.
[9]	Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395(2020): 809-15.
[10]	Fornari F. Vertical Transmission of Covid-19-A Systematic review. J Pediatr Perinatol Child Heal. 2020; 4(2): 7-13.
[11]	Sisman J, Jaleel MA, Moreno W, Rajaram V, Collins RRJ, Savani RC, et al. Intrauterine transmission of SARS-COV-2 infection in a preterm infant. Pediatr Infect Dis J. 2020; XX(XX, XXX XXX): 1-3.
[12]	Vivanti AJ, Vauloup-fellous C, Prevot S, Zupan V, Suffee C, Cao J Do, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun [Internet]. 2020; 2020(11): 1-7.
[13]	Alzamora MC, Paredes T, Valdez LM, Rosa M La, Caceres D, Webb CM. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020; 1(212): 861-5.
[14]	Pulinx B, Kieffer D, Michiels I, Petermans S, Strybol D, Delvaux S, et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis. 2020.
[15]	Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am Soc Clin Pathol. 2020; 23-32.
[16]	Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V. Systematic review outcome of coronavirus spectrum infections a systematic review and meta-analysis. Am J Obstet Gynecol MFM [Internet]. 2020; 2(2): 100107.
[17]	Id VS, Id DS, Warty R, Payne O, Salih M, Chin KL, et al. Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. PLoS One [Internet]. 2020; 6(4): 1-13.
[18]	Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020; 174(7): 0-3.
[19]	Zamaniyan M, Ebadi A, Mir SA, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenat Diagnosis (Epub ahead print). 2020.
[20]	Hosier H, Farhadian S, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, et al. SARS-CoV-2 infection of the placenta. medRxiv. 2020.
[21]	Blumberg DA, Underwood MA, Hedriana HL, Lakshminrusimha S. Vertical transmission of SARS-CoV-2: What is the optimal definition? Am J Perinatol. 2020; 7(8): 769-72.
[22]	Lamouroux A, Attie-Bitach T, Martinovic J, Leruez-Ville M, Ville Y. Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. Am J Obstet Gynecol. 2020.
[23]	Bhat BV. Challenges in neonatal COVID-19 infection. Indian J Pediatr. 2020; 87(8): 577-8.
[24]	Patel KP, Vunnam SR, Patel PA, Krill KL, Korbitz PM, Gallagher JP, et al. Transmission of SARS-CoV-2: an update of current literature. Eur J Clin Microbiol Infect Dis. 2020.
[25]	Singhal T. A Review of coronavirus disease-2019 (COVID-19). Indian J Pediatr. 2020; 87(4): 281-6.