A Clinical Trial of Nitazoxanide and Albendazole in Biliary Ascariasis

Hasina Nasreen^1,

¹Tropical Medicine, Bangladesh Institute of Tropical and Infectious Diseases (BITID), Chittagong, Bangladesh

Cite this paper:
Hasina Nasreen. A Clinical Trial of Nitazoxanide and Albendazole in Biliary Ascariasis. American Journal of Medicine Studies. 2017; 5(1):18-24. doi: 10.12691/ajms-5-1-2

Abstract

A clinical trial was conducted in 2009 to evaluate the efficacy of albendazole and nitazoxanide in case of biliary ascariasis patients admitted in the medicine ward of Chittagong Medical College Hospital (CMCH), Bangladesh. The clinical trial was carried out between two study groups, individually group A and Group B, where group A patients were treated with Albendazole and group B patients with Nitazoxanide. Albendazole was administered (400mg) tablet single dose and Nitazoxanide (500mg) tablet were twelve hourly for 3 days. Relieve of pain time after taking antihelminthics were recorded and serial ultrasonograms (USG) were performed to observe the worm present or absent in biliary tree. Most of the respondents were within 18 to 35 years age group and it was about 68%. The patients were admitted with different clinical complications where most of them complaints of vomitting. Among the total respondents, about 87% were cured, while only 13% were not cured off their diseases. It was also noted that, the cure rate is more in nitazoxanide (89 Vs 85%), while the percentage of not cured individuals were more in albendazole (15 Vs 11%). The association between study groups and treatment outcome was not found to be statistically significant (P>0.05). There were no significant adverse effects or abnormalities in clinical chemistry values.

Keywords:
helminth infections ascariasis albendazole nitazoxanide

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Shah O. J, Rabbani M.S. Irfan, M.D, Khan F. M.S, Zargar S. A.M.D., D.M, Gul Javid, G M.D, Management of biliary ascariasis in pregnancy Published online September 15, 2005. World J.Surg. 29, 1294-1298 (2005).
[2]	Albendazole: A review of antihelminthic efficacy and safety in humans. Parasitology (2000), 12: S113-s132 cambridge university press. Copyright © 2001 Cambridge university press. Published on line by Cambridge university press 15 June 2001.
[3]	Das UK(1), Karim M(2), Raihan ASMA(3), Hasan M(4). Biliary ascariasis: Experience from a district Hospital. The ORION 2008, 31: 585-587.
[4]	Shah O J M S, Zargar A, MD, MA. Rabbani S.I M D. Biliary ascariasis: A Review Showkat World health journal of surgery © 2006 by the society in ternational de chirurgic World J Surg (2006) 30: 1500-1506.
[5]	Chak DRH Ascariasis: Treatment and Medication: Updated Sep 12, 2008.
[6]	Helminthol J, [2007] Nitazoxanide in the treatment of ascaris Lumbricoids September 81(3): 255-9, Epub 2007 Jun.
[7]	Ortiz JJ (1), Chegni NL (1), Gargala G (2), Favennec L.(2) Comparative Clinical Studies of Nitazoxanide, Albendazole and praziquantel in the treatment of ascariasis Translocation of the Royal Society of Tropical Medicine and hygiene Volume 96, Issue2, Pages 193-196 (March 2002).
[8]	Shoff WH, MD DTM & H. Ascariasis: American Society of Tropical Medicine Article last updated Jun 11, 2008.
[9]	Akhter N, Islam SMM, Mahmood S, Hossain GA, Chakroborty RK, Prevalence of Biliary ascariasis and its relation to biliary lithiasis. Received April 15, 2005/Accepted July 25, 2008. J Med Untrasonics (2006) 33:55-59.
[10]	Haburchak DR MD, Ascariasis Article Article Last updated Sep, 12, 2008.
[11]	Dr. Ali A, Review of Management of biliary ascariasis JCMTA 2003; 14(2):29-38.
[12]	Khuroo MS, Ascariasis Gastroenterology Clinics- Volume 25, Issue 3 (September 1996).
[13]	Alam Shahinul, Mustafa Golam, Ahmed Nooruddin, Khan Mobin. Presentation and Endoscopic management of biliary ascariasis J. Trop,Md Public health, South East Asian. Vol 38 N, 4 July 2007.
[14]	Mukhopadhyay Madhumita Biliary Ascariasis in the Indian Subcontinent: A study of 42 cases The Saudi Journalist of Gastroenterology Volume 15, Number2 April 2009.