Systematic Review of the Role of Mannitol in Renal Diseases

Tian-Biao Zhou^1, and Zong-Pei Jiang¹

¹Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

Cite this paper:
Tian-Biao Zhou and Zong-Pei Jiang. Systematic Review of the Role of Mannitol in Renal Diseases. American Journal of Medicine Studies. 2014; 2(2):31-33. doi: 10.12691/ajms-2-2-1

Abstract

Mannitol, a novel osmotic agent and natural polyol extensively, is sometimes effective in reversing acute renal injury, but it can also induce the acute renal tubular injury. The role of mannitol in kidney is controversial. It is a small particle, distributed only in the extracellular space, is freely filtered at the glomerulus, and is not reabsorbed by the tubules. This systematic review was conducted to sum up the association of mannitol with renal diseases. The mannitol may precipitate acute renal failure if serum osmolarity exceeds 320 mOsm/L, but the lower concentration might be positive. However, more studies should be performed in the future.

Keywords:
mannitol osmotic diuretic osmotic nephrosis acute renal failure systematic review

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