Emergence of Monkeypox Raises a Serious Challenge to Public Health

Mahendra Pal^1, and Kirubel Paulos Gutama²

¹Narayan Consultancy on Veterinary Public Health and Microbiology, Anand, India

²Adaba District Livestock and Fishery Development and Resource, West Arsi, Ethiopia

Cite this paper:
Mahendra Pal and Kirubel Paulos Gutama. Emergence of Monkeypox Raises a Serious Challenge to Public Health. American Journal of Microbiological Research. 2022; 10(2):55-58. doi: 10.12691/ajmr-10-2-2

Abstract

Monkeypox is an emerging and re-emerging viral zoonotic disease caused by the Monkeypox virus, which is considered the most important Orthopoxvirus infection since smallpox eradication. Although most cases are documented in Central and West Africa, there have been sporadic cases reported all across the world, sometimes involving travelers. Outside of Africa, the current outbreak is the largest ever. Close personal contact is how Monkeypox virus spreads. The most prevalent routes of infection for humans include respiratory, percutaneous, and permucosal exposures to infected monkeys, zoo animals, prairie dogs, and people. Flu-like symptoms (fever, fatigue, and muscular aches), swollen lymph nodes, and a rash are all commonly observed in monkeypox. The rash can develop anywhere on the body, including the face, genitals, palms, and soles of the feet. The prognosis of the disease in immunocompromised patients is poor. The techniques for the diagnosis of the disease include laboratory culture, polymerase chain reaction (PCR), immunohistochemistry, and electron microscopy. Antiviral drugs such as tecovirimat, cidofovir, and brincidofovir, which are used to treat smallpox, can also be used for monkeypox. Ring vaccination, or targeted smallpox immunization for close contacts of an infected individual, can be used to reduce monkeypox. JYNNEOS is a non-replicating smallpox and monkeypox vaccination that is newer and safer. Other monkeypox vaccines, such as VAC6 and LC16.20, are in the development stage.

Keywords:
emerging and re-emerging Monkeypox Monkeypox virus public health worldwide Zoonosis

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References:

[1]	Dong, X. and Soong, L. “Emerging and re-emerging zoonoses are major and global challenges for public health”. Zoonoses, 1. 1-4. June 2021.
[2]	Kobayashi, N. “Impact of emerging, re-Emerging and zoonotic viral infectious diseases, in a virologist’s perspective”. The Open Virology Journal, 12. 131-133. September 2018.
[3]	Venkatesion, G., Balamurugan,V., Gandhale, P., Singh, R. and Bhanuparkash,V. “Viral zoonoses: A comprehensive review”. Asian Journal of Animal and Veterinary Advances, 5. 77-92. February 2010.
[4]	Pal, M. “Public health concern due to emerging and re-emerging zoonoses”. International Journal of Livestock Research, 3. 56-62. January 2013.
[5]	Pal, M. “Importance of zoonoses in public health”. Indian Journal of Animal Sciences, 75.586-591. May 2005.
[6]	Pal, M. “Severe acute respiratory syndrome: A newly recognized viral zoonosis of public health concern”. Acta Scientific Microbiology, 1.1. May 2018.
[7]	Pal, M., Singh, R., Gutama, P.K., Savalia, C.V. and Thakur, R. “Human monkeypox: An emerging and re-emerging infectious viral disease”. Acta Scientific Microbiology, 5. 146-150. April 2022.
[8]	CDC. “Monkeypox”. Centers for Disease Control and Prevention, Atlanta, Georgia, USA. January 2021.
[9]	WHO. “Monkeypox Fact Sheet”. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/monkeypox. September 2019. (Accessed May 24, 2022).
[10]	Petersen, E., Kantele, A. and Koopmans, M. “Human monkeypox”. Infectious Disease Clinics of North America, 33. 1027-1043. January 2019.
[11]	Likos, A.M., Sammons, S.A., Olson, V.A., Frace, A.M., Li, Y., Olsen-Rasmussen, M., Davidson,W., Galloway, R., Khristova, M.L., Reynolds, M.G., Zhao, H., Carroll, D.S., Curns, A., Formenty, P., Esposito, J.J., Regnery, R.L. and Damon, I.K. “A tale of two clades: monkeypox viruses”. Journal of General Virology, 86. 2661-72. November 2005.
[12]	WHO. “Outbreaks and Emergencies Bulletin”. World Health Organization Health Emergencies Programme. Available at: https://apps.who.int/iris/handle/10665/353573. April 2022. (Accessed May 25, 2022).
[13]	ECGC. “Epidemiological update: Monkeypox multi-country outbreak”. European Centre for Disease Prevention and Control Available at:https:// www.ecdc.europa.eu. May 2022. (Accessed May 26, 2022).
[14]	Beer, E.M. and Rao, V.B. “A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy”. PLoS Neglected Tropical Disease, 13. e0007791. October 2019.
[15]	Yinka-Ogunleye, A., Aruna, O., Dalhat, M., Ogoina, D., McCollum, A., Disu. YA., Mamadu, I., Akinpelu, A., Ahmad, A., Burga, J. and Saleh, M. “Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report”. Lancet Infectious Disease, 19. 872-79. July 2019.
[16]	Learned, L.A., Reynolds, M.G., Wassa, D.W., Li, Y., Olson, V.A., Karem, K., Stempora, L.L., Braden, Z.H., Kline, R., Likos, A., Libama, F., Moudzeo, H., Bolanda, J.D., Tarangonia, P., Boumandoki, P., Formenty, P., Harvey, J.M. and Damon, I.K. “Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003”. American Journal of Tropical Medicine and Hygiene, 73.428–34. August 2005.
[17]	WHO. “Human monkeypox in Nigeria”. World Health Organization Available at: https://www.who.int/csr/don/05-october-2018-monkeypox-nigeria/en/. July 2018. (Accessed May 23, 2022).
[18]	CDC. “Monkeypox signs and symptoms”. US Centers for Disease Control and Prevention. https://www.cdc.gov/poxvirus/monkeypox/symptoms.html. November 2021. (Accessed May 24, 2022).
[19]	Rimoin, A.W., Mulembakani, P.M., Johnston, S.C., Lloyd, J.O., Smith, B.E., Kisaluf, N.K., Kinkelac,T.L., Seth Blumberg, S.B., Thomasseng, H.A., Pikeh, B.L., Fairh, J.N., Wolfeh, N.D., Shongoi, R.L., Grahamj, B.S. and Jean-Jacques Muyemben, J.S. “Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo”. Proceedings of the National Academy of Sciences of the United States of America, 107. 16262-7. September 2010.
[20]	Petersen, B.W., Kabamba, J., McCollum, A.M., Lushima, R.S., Wemakoy, E.O.,Tamfum, J.J., Nguete, B. and Reynold, M.G. “Vaccinating against monkeypox in the Democratic Republic of the Congo”. Antiviral Research, 162.171-177. November 2018.
[21]	Hobson, G., Adamson, J.M., Adler, H., Firth, R., Gould,S., Houlihan, C., Johnson, C., Porter, D., Rampling, T., Ratcliffe, L., Russell, K., Shankar, A.G. and Wingfield, T. “Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom”. Eurosurveillance, 26.1-4. May 2021.
[22]	MDPH. “Massachusetts public health officials confirm case of monkeypox”. Massachusetts Department of Public Health. Available at https://www.mass.gov/news/massachusetts-public-health-officials-confirm-case-of-monkeypox. May 2022. (Accessed May 24, 2022).
[23]	Monkeypox Tracker - USA. BNO News. Available at https://bnonews.com/monkeypox/USA.html. May 2022. (Accessed May 24, 2022).
[24]	Monkeypox Tracker – Worldwide. BNO News. Available at https://bnonews.com/monkeypox/Worldwide.html. May 2022. (Accessed May 24, 2022).
[25]	Osadebe, L., Hughes, C.M., Shongo Lushima, R., et al. “Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo”. PLoS Negelected Tropical Disease, 11.e0005857. September 2017.
[26]	McCollum, A.M and Damon, I.K. “Human monkeypox”. Clinical Infectious Disease, 58.260-267. October 2013.
[27]	Moore, M. and Zahra, F. Monkeypox. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK574519. May 2022.
[28]	CDC. “Monkeypox treatment”. US Centers for Disease Control and Prevention. https://www.cdc.gov/poxvirus/monkeypox/clinicians/treatment.html. May 2022. (Accessed May 23, 2022).
[29]	WHO. “WHO advisory committee on variola virus research: report of the twenty-third meeting, virtual meeting”, World Health Organization, Geneva, Switzerland. November 2021.
[30]	Pal, M., Mengstie, F. and Kandi, V. “Epidemiology, diagnosis, and control of monkeypox disease: A comprehensive review.” American Journal of Infectious Diseases and Microbiology,. 5. 94-99. June 2017.
[31]	CDC. “Monkeypox and smallpox vaccine guidance”. US Centers for Disease Control and Prevention. https://www.cdc.gov/poxvirus/monkeypox/ clinicians/smallpox-vaccine.html. June 2022. (Accessed May 25, 2022).